CD68

CD68 is a protein that in humans is encoded by the CD68 gene. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes in lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type of glycoprotein and is found in macrophages and derived from a hematopoietic stem cell.

Function

CD68 is a heavily glycosylated transmembrane protein that is expressed in several tissues of the body. It is particularly abundant in macrophages and other cells of the mononuclear phagocyte system. The protein serves as a marker for these cells, allowing them to be identified and studied. CD68 is involved in the uptake and degradation of material by cells, a process known as phagocytosis. It is also thought to play a role in the immune response.

Clinical significance

CD68 is used as a diagnostic tool in pathology. It is used to identify the presence of macrophages in tissue samples, which can indicate an immune response. It is also used to identify certain types of tumors, particularly those derived from monocytes or macrophages. CD68 is also used in research to understand the role of macrophages in disease.

See also

• Macrophage
• Monocyte
• Phagocytosis
• Glycoprotein
• Lysosome
• Endosome

References

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