CD14

CD14 is a human gene that encodes for the CD14 protein. CD14 is a part of the immune system and plays a crucial role in the process of inflammation. It is a pattern recognition receptor that can recognize molecules that are commonly associated with pathogens.

Function

The CD14 protein is a key player in the innate immune response. It is a pattern recognition receptor that can recognize molecules that are commonly associated with pathogens, such as lipopolysaccharides (LPS). When CD14 binds to LPS, it triggers a series of events that lead to an inflammatory response. This response is crucial for the body's defense against infections.

CD14 can be found on the surface of certain cells, such as monocytes and macrophages, where it is anchored by a glycosylphosphatidylinositol tail. However, a soluble form of CD14 (sCD14) can also be found in the serum.

Clinical significance

Alterations in the CD14 gene or protein have been associated with several diseases. For instance, increased levels of sCD14 have been found in patients with sepsis, and it has been suggested that sCD14 levels could be used as a biomarker for this condition.

Furthermore, polymorphisms in the CD14 gene have been linked to atopy and asthma. Specifically, the -159C/T polymorphism has been associated with an increased risk of these conditions.

See also

• Innate immune system
• Pattern recognition receptor
• Lipopolysaccharide
• Monocyte
• Macrophage
• Sepsis
• Atopy
• Asthma

References

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