Adamantyl-THPINACA

Adamantyl-THPINACA

Synthetic cannabinoid

Adamantyl-THPINACA is a synthetic cannabinoid that has been identified in various designer drug products. It is a potent agonist of the cannabinoid receptors and is structurally related to other synthetic cannabinoids used recreationally.

Chemical structure

Adamantyl-THPINACA belongs to the class of synthetic cannabinoids known as indazole-3-carboxamides. The compound features an adamantyl group, which is a bulky, cage-like structure, attached to the indazole core. This structural modification is believed to influence the compound's binding affinity and activity at cannabinoid receptors.

Pharmacology

Synthetic cannabinoids like Adamantyl-THPINACA act on the CB1 and CB2 receptors in the endocannabinoid system. These receptors are part of the G protein-coupled receptor family and are involved in various physiological processes, including pain sensation, mood regulation, and appetite control. Adamantyl-THPINACA is known to be a potent agonist, meaning it can strongly activate these receptors, leading to effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.

Legal status

Due to its potential for abuse and lack of medical use, Adamantyl-THPINACA is classified as a controlled substance in many jurisdictions. The legal status of synthetic cannabinoids can vary widely, with some countries implementing blanket bans on entire classes of compounds to prevent the emergence of new analogs.

Health effects

The use of synthetic cannabinoids like Adamantyl-THPINACA can lead to a range of adverse health effects. These may include tachycardia, hypertension, nausea, vomiting, anxiety, paranoia, and hallucinations. In severe cases, use can result in seizures, renal failure, and even death. The unpredictable nature of these compounds, combined with their high potency, makes them particularly dangerous.

Detection in biological samples

Adamantyl-THPINACA can be detected in biological samples using advanced analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). These methods allow for the identification and quantification of the compound in blood, urine, and other biological matrices, which is crucial for forensic and clinical toxicology.

Related pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Designer drug
• Tetrahydrocannabinol

Gallery

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  Chemical structure of Adamantyl-THPINACA