Advaxis
American biotechnology company
Advaxis is an American biotechnology company focused on the development of cancer immunotherapies. The company is known for its proprietary Listeria monocytogenes-based antigen delivery platform, which is designed to stimulate the immune system to target and destroy cancer cells.
History
Advaxis was founded in 2002 and is headquartered in Princeton, New Jersey. The company was established to develop and commercialize the innovative research conducted by Dr. Yvonne Paterson at the University of Pennsylvania.
Technology
Advaxis utilizes a unique approach to cancer treatment by employing a live-attenuated strain of the bacterium Listeria monocytogenes to deliver tumor-associated antigens directly to the immune system. This method is intended to enhance the body's natural ability to recognize and attack cancer cells.
Listeria monocytogenes Platform
The Listeria monocytogenes platform is designed to stimulate both the innate and adaptive immune responses. The bacteria are engineered to express specific antigens associated with cancer cells, which are then presented to the immune system, prompting a targeted immune response.
Pipeline
Advaxis has developed several product candidates targeting various types of cancer, including cervical cancer, prostate cancer, and head and neck cancer. These candidates are in various stages of clinical development.
ADXS-HPV
ADXS-HPV is one of Advaxis's lead product candidates, targeting human papillomavirus (HPV)-associated cancers. It is designed to elicit an immune response against HPV-infected cells, which are often precursors to cervical cancer.
ADXS-PSA
ADXS-PSA is being developed for the treatment of prostate cancer. It targets the prostate-specific antigen (PSA), a protein produced by both normal and malignant prostate cells.
ADXS-HER2
ADXS-HER2 is aimed at treating HER2-expressing cancers, such as certain types of breast cancer and gastric cancer.
Collaborations
Advaxis has entered into several strategic collaborations with other biotechnology and pharmaceutical companies to advance its pipeline and expand the potential applications of its technology.
See also
Related pages
Gallery
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Logo of Advaxis
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