MK-212

MK-212 is a serotonin receptor agonist that is primarily used in scientific research. It is a potent and selective 5-HT2C receptor agonist, and has been used to develop a number of new serotonin receptor agonists with improved properties.

Pharmacology

MK-212 has a high affinity for the 5-HT2C receptor, and is one of the most potent 5-HT2C receptor agonists known. It also has moderate affinity for the 5-HT2A receptor and 5-HT2B receptor, and low affinity for the 5-HT1A receptor. MK-212 has been used in scientific research to investigate the role of the 5-HT2C receptor in various physiological processes and diseases, including obesity, depression, and schizophrenia.

Chemistry

MK-212 is a tryptamine derivative, and is structurally related to the naturally occurring neurotransmitter serotonin. It is a chiral compound, and both the (R)- and (S)-enantiomers have been synthesized and studied. The (R)-enantiomer is the more potent of the two.

Research

Research into the potential therapeutic uses of MK-212 has focused on its effects on the 5-HT2C receptor. Studies have shown that MK-212 can reduce food intake and body weight in animal models of obesity, suggesting that it may have potential as a treatment for obesity. Other research has investigated the potential use of MK-212 in the treatment of depression and schizophrenia, based on its ability to modulate serotonin receptor activity.

See also

• 5-HT2C receptor
• Serotonin receptor agonist
• Tryptamine

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