Diphenidine

Diphenidine is a dissociative anesthetic that has been sold as a designer drug. The synthesis of diphenidine was first reported in 1924, and employed a Buchwald-Hartwig amination. The drug is believed to have NMDA receptor antagonist activity and is thus similar to ketamine and phencyclidine.

History

Diphenidine was first reported in a 1924 patent where it was tested as an anesthetic. The patent described the synthesis of diphenidine and included animal testing on rats, which showed anesthetic properties. However, it was not until the 21st century that diphenidine was sold as a recreational drug.

Pharmacology

Diphenidine is a NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the "K-hole" or "dissociative hole".

Legal Status

As of October 2015, Diphenidine is a controlled substance in China. In the United Kingdom, it is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See Also

• Methoxphenidine
• Ephenidine
• MT-45

References

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