O-2050

O-2050 is a synthetic cannabinoid that is used in scientific research. It is a selective agonist for the peripheral CB2 receptor, and has been used in a variety of studies to explore the role of this receptor in immune function, pain, and other physiological processes.

Chemistry

O-2050 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally similar to other cannabinoids such as JWH-018 and HU-210, but differs in that it has a sulfonamide group, which is believed to be responsible for its selectivity for the CB2 receptor.

Pharmacology

O-2050 acts as a selective agonist for the CB2 receptor, with a Ki value of 23.4 nM. This makes it one of the most potent CB2-selective agonists currently known. It has been shown to produce anti-inflammatory effects in animal models, and has also been used to study the role of the CB2 receptor in pain perception.

Research uses

Due to its selectivity for the CB2 receptor, O-2050 has been used in a variety of research studies. These have included investigations into the role of the CB2 receptor in immune function, the potential therapeutic uses of CB2 agonists in conditions such as chronic pain and inflammatory bowel disease, and the effects of CB2 activation on neuroinflammation and neurodegeneration.

See also

• Cannabinoid receptor
• Cannabinoid receptor type 2
• Synthetic cannabinoids

References

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