WNT10A

WNT10A is a gene that provides instructions for making a protein that is part of the WNT family of proteins. These proteins play critical roles in cell growth, division, and specialization (differentiation). The WNT10A protein is involved in the formation of several types of tissues, including hair, teeth, and nails.

Function

The WNT10A protein is a member of the WNT family, a group of signaling proteins that play a role in embryonic development. The WNT10A protein is involved in the differentiation of epithelial cells, which line the surfaces of the body and its cavities. It is also involved in the development of hair follicles, teeth, and nails.

Clinical significance

Mutations in the WNT10A gene have been associated with several conditions, including odontoma, ectodermal dysplasia, and Schöpf-Schulz-Passarge syndrome. These conditions are characterized by abnormalities in the development of hair, teeth, and nails.

Genetics

The WNT10A gene is located on the short (p) arm of chromosome 2 at position 25.3. The gene spans approximately 23 kilobases and contains 5 exons. Mutations in this gene can lead to a variety of conditions, depending on the nature and location of the mutation.

See also

• WNT signaling pathway
• Ectodermal dysplasia
• Odontoma
• Schöpf-Schulz-Passarge syndrome

References

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External links

• NCBI Gene
• Genetics Home Reference

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