DMRT1
DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1) is a gene that encodes a protein involved in sexual development in humans and other animals. This gene is part of the DMRT gene family, which is named for its two key members: doublesex in Drosophila and mab-3 in Caenorhabditis elegans.
Function
The DMRT1 gene provides instructions for making a protein that plays a crucial role in the development of male sexual characteristics. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. In particular, the DMRT1 protein appears to be essential for the development and maintenance of Sertoli cells, which are specialized cells in the testes that are necessary for normal male sexual development.
Clinical significance
Mutations in the DMRT1 gene can lead to disorders of sex development (DSDs), including gonadal dysgenesis and testicular regression syndrome. These conditions are characterized by atypical development of sexual characteristics and can lead to infertility.
See also
References
<references />
External links
Ad. Transform your life with W8MD's
GLP-1 weight loss injections special from $29.99 with insurance
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
