CD137

CD137 or 4-1BB is a protein that in humans is encoded by the TNFRSF9 gene. It is a member of the tumor necrosis factor (TNF) receptor superfamily. It is an inducible T cell co-stimulator that may play a crucial role in the longevity and proliferation of immune responses.

Function

CD137 is a co-stimulatory molecule that is expressed by antigen-stimulated T lymphocytes. It interacts with a ligand (4-1BBL) expressed by macrophages and antigen-presenting cells (APCs), providing a two-way signal that aids in the activation of the T-cells and the production of cytokines. CD137 and its ligand play a crucial role in the induction and maintenance of the immune response.

Clinical Significance

CD137 has been implicated in a variety of diseases, including cancer, autoimmune diseases, and infectious diseases. In cancer, CD137 stimulation has been shown to enhance anti-tumor immunity, and agonistic antibodies against CD137 are currently being tested in clinical trials for cancer treatment. In autoimmune diseases, CD137 has been shown to play a role in the pathogenesis of diseases such as rheumatoid arthritis and multiple sclerosis. In infectious diseases, CD137 has been shown to enhance the immune response to pathogens.

See Also

• Tumor necrosis factor receptor
• Cytokines
• Macrophages
• Antigen-presenting cells
• Rheumatoid arthritis
• Multiple sclerosis

References

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