Translational research

Translational research is a type of research that aims to improve the health of individuals and the community by "translating" findings in fundamental research into medical practice and meaningful health outcomes. Translational research, often used interchangeably with translational medicine or translational science or bench to bedside, is an highly interdisciplinary field, the primary goal of which is to coalesce assets of various natures within the individual pillars in order to improve the global healthcare system significantly.

Definition

The process of translational research, which is often depicted as a biomedical research "pipeline," involves multiple stages. The first stage of translational research (T1) involves applying discoveries from the laboratory to develop trials and studies in humans. The second stage (T2) involves enhancing the adoption of best practices, while the third stage (T3) seeks to understand how to best implement these improved practices in the real world.

Stages

T1: Bench to Bedside

The T1 stage of translational health research refers to the “bench-to-bedside” enterprise of translating knowledge from the basic sciences into the development of new treatments. This stage involves preclinical research, such as in vitro or animal testing, and also the development of clinical trial methodologies.

T2: Bedside to Clinical Practice

The T2 stage involves the enhancement of best practices in the community. This stage involves studies of the effectiveness of these new treatments in large populations, the development of guidelines, and the decision making involved in the use of these new treatments.

T3: Clinical Practice to Population Health Impact

The T3 stage involves research to increase the uptake and implementation of best practices into the community. This stage involves research on implementation strategies and health services research.

Challenges

Translational research is a complex, resource-intensive process that requires collaboration, coordination, and the sharing of knowledge. Challenges include the need for more researchers trained in translational research, the need for more funding, and the need for more collaboration between researchers and healthcare providers.

See also

• Clinical research
• Health services research
• Implementation science
• Medical research
• Preclinical research

References

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