Uramustine

Uramustine, also known as Uracil Mustard, is a chemotherapy drug that is used in the treatment of certain types of cancer. It belongs to the class of drugs known as alkylating agents, which work by damaging the DNA of cancer cells and preventing them from dividing and growing.

Mechanism of Action

Uramustine works by binding to the DNA in cancer cells and interfering with its function. This prevents the cancer cells from dividing and growing, which can slow or stop the growth of the cancer. The exact mechanism of action of uramustine is not fully understood, but it is thought to work by forming a covalent bond with the DNA molecule, which interferes with its function.

Uses

Uramustine is used in the treatment of certain types of cancer, including non-Hodgkin lymphoma and chronic lymphocytic leukemia. It may be used alone or in combination with other chemotherapy drugs.

Side Effects

Like all chemotherapy drugs, uramustine can cause side effects. These may include nausea, vomiting, diarrhea, and hair loss. More serious side effects can include bone marrow suppression, which can lead to a decrease in the number of blood cells in the body, and liver damage.

Precautions

Before starting treatment with uramustine, patients should discuss any other medications they are taking with their doctor, as uramustine can interact with other drugs. Patients should also be monitored closely for signs of bone marrow suppression and liver damage.

See Also

• Chemotherapy
• Alkylating agent
• Non-Hodgkin lymphoma
• Chronic lymphocytic leukemia

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