Levacetylmethadol

Levacetylmethadol (also known as LAAM) is a synthetic opioid similar in structure to methadone. It has a long duration of action due to its active metabolites. LAAM was used in the treatment of opioid addiction. The use of LAAM has been discontinued in Europe and U.S.A due to concerns of cardiac arrhythmias.

Pharmacology

LAAM is a synthetic opioid that is converted in the liver to active metabolites including nor-LAAM and dinor-LAAM. These metabolites are stored in body tissues and slowly released, prolonging the duration of action. LAAM is more fat-soluble than methadone, contributing to its longer duration of action.

Medical Use

LAAM was used as a replacement therapy for opioid addiction. It was administered three times a week, compared to daily administration required for methadone. This made it a more convenient option for patients and healthcare providers.

Side Effects

The most common side effects of LAAM include constipation, drowsiness, dry mouth, and sweating. Serious side effects may include respiratory depression, low blood pressure, and cardiac arrhythmias.

Discontinuation

The use of LAAM has been discontinued in Europe and U.S.A due to concerns of cardiac arrhythmias. In 2001, the U.S. Food and Drug Administration issued a warning about the potential for LAAM to cause serious heart rhythm problems in some patients.

See Also

• Opioid
• Methadone
• Opioid addiction
• Food and Drug Administration

References

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