Aggrecanase
Aggrecanase is an enzyme in the connective tissue that plays an important role in the pathogenesis of arthritis and other connective tissue diseases.
Role of aggrecanases
Aggrecanases are extracellular proteolytic enzymes.
ADAMTS family
Aggrecanases belong to a group of protein cleaving enzymes called ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family.
Mechanism of action
Aggrecanases act on large proteoglycans known as aggrecans, which are components of connective tissues such as cartilage.
Clinical significance
The inappropriate activity of aggrecanase is a mechanism by which cartilage degradation occurs in diseases such as arthritis.
Types of aggrecanases
There are two forms of aggrecanase exist in humans: ADAMTS4 or aggrecanase-1[1] and ADAMTS5 or aggrecanase-2.
External links
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