Goblet cell

Goblet cell is a type of cell found in the respiratory and intestinal tracts, which secretes the main component of mucus.

Function

Goblet cells are glandular, simple columnar epithelial cells whose function is to secrete gel-forming mucins, the major components of mucus. The goblet cells mainly use the apocrine method of secretion, which involves the budding off of secretory vesicles. The goblet cells are found in the trachea (windpipe) and the large intestine.

Structure

Goblet cells are simple columnar epithelial cells, but they have many adaptations that suit them to their role. On their apical surface, they possess a thin striated border and over this, a thick coat of mucus. Their cytoplasm is full of granules (the vesicles that contain the mucus), which are released by exocytosis. They have a relatively small base and a large apical area, which is packed with these granules. This gives them their characteristic goblet shape.

Clinical significance

Goblet cell numbers can change in response to stress, for example, in asthma, where there is an increase in goblet cells. This leads to a condition known as goblet cell hyperplasia. In addition, goblet cells are also involved in the pathogenesis of some diseases, such as chronic bronchitis and ulcerative colitis.

See also

• Mucus
• Epithelial cell
• Respiratory tract
• Intestinal tract

References

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  Histopathology of goblet cells and foveolar cells in incomplete Barrett's esophagus