Nitrendipine

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Nitrendipine is a calcium channel blocker of the dihydropyridine class. It is used in the treatment of hypertension and angina pectoris.

Mechanism of Action

Nitrendipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Indications

Nitrendipine is indicated for the management of hypertension. It may be used alone or in combination with other antihypertensive agents.

Side Effects

Common side effects of Nitrendipine include headache, dizziness, flushing, and nausea. Serious side effects may include low blood pressure, heart failure, and arrhythmias.

Contraindications

Nitrendipine is contraindicated in patients with known hypersensitivity to dihydropyridines.

Drug Interactions

Nitrendipine may interact with other drugs such as beta blockers, digoxin, cimetidine, and warfarin.

Dosage

The usual starting dose of Nitrendipine is 10 mg once daily. The dose may be increased according to the patient's response.

References

  • Drug Information Handbook. Lexi-Comp, 2007.
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  • Structural formula of (RS)-Nitrendipine
    Structural formula of (RS)-Nitrendipine
  • 3D ball model of Nitrendipine
    3D ball model of Nitrendipine
  • Structural formula of (R)-Nitrendipine
    Structural formula of (R)-Nitrendipine
  • Structural formula of (S)-Nitrendipine
    Structural formula of (S)-Nitrendipine
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