Large-cell acanthoma: Difference between revisions
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{{Infobox medical condition | |||
| name = Large-cell acanthoma | |||
| image = [[File:SkinTumors-P6120248.JPG|left|thumb|Large-cell acanthoma]] | |||
| caption = Large-cell acanthoma on the skin | |||
| field = [[Dermatology]] | |||
| synonyms = | |||
| symptoms = [[Skin lesion]] | |||
| complications = | |||
| onset = | |||
| duration = | |||
| causes = Unknown | |||
| risks = | |||
| diagnosis = [[Skin biopsy]] | |||
| differential = [[Seborrheic keratosis]], [[Actinic keratosis]] | |||
| prevention = | |||
| treatment = [[Cryotherapy]], [[Laser therapy]], [[Surgical excision]] | |||
| medication = | |||
| prognosis = | |||
| frequency = | |||
| deaths = | |||
}} | |||
'''Large-cell acanthoma''' is a benign [[skin lesion]] that is characterized by its large, pale-staining keratinocytes. It is a rare condition that is often mistaken for other skin conditions, such as [[actinic keratosis]] or [[squamous cell carcinoma]]. | '''Large-cell acanthoma''' is a benign [[skin lesion]] that is characterized by its large, pale-staining keratinocytes. It is a rare condition that is often mistaken for other skin conditions, such as [[actinic keratosis]] or [[squamous cell carcinoma]]. | ||
== History == | == History == | ||
Large-cell acanthoma was first described in 1968 by the dermatologist [[Robert Degos]]. It was initially thought to be a variant of [[seborrheic keratosis]], but further studies have shown that it is a distinct entity. | Large-cell acanthoma was first described in 1968 by the dermatologist [[Robert Degos]]. It was initially thought to be a variant of [[seborrheic keratosis]], but further studies have shown that it is a distinct entity. | ||
== Characteristics == | == Characteristics == | ||
Large-cell acanthoma typically presents as a solitary, well-demarcated, flat or slightly raised lesion. It is usually found on sun-exposed areas of the body, such as the face, neck, and arms. The lesion is often asymptomatic, but it may cause mild itching or discomfort. | Large-cell acanthoma typically presents as a solitary, well-demarcated, flat or slightly raised lesion. It is usually found on sun-exposed areas of the body, such as the face, neck, and arms. The lesion is often asymptomatic, but it may cause mild itching or discomfort. | ||
Histologically, large-cell acanthoma is characterized by an increased number of large, pale-staining keratinocytes in the epidermis. These cells are larger than the surrounding keratinocytes and have a clear or pale cytoplasm. The dermis underneath the lesion may show signs of solar elastosis, indicating chronic sun damage. | Histologically, large-cell acanthoma is characterized by an increased number of large, pale-staining keratinocytes in the epidermis. These cells are larger than the surrounding keratinocytes and have a clear or pale cytoplasm. The dermis underneath the lesion may show signs of solar elastosis, indicating chronic sun damage. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of large-cell acanthoma is usually made based on the clinical appearance of the lesion and the histological findings. A skin biopsy may be performed to confirm the diagnosis and to rule out other skin conditions. | The diagnosis of large-cell acanthoma is usually made based on the clinical appearance of the lesion and the histological findings. A skin biopsy may be performed to confirm the diagnosis and to rule out other skin conditions. | ||
== Treatment == | == Treatment == | ||
Treatment for large-cell acanthoma is usually not necessary, as the condition is benign and does not pose a risk for malignancy. However, if the lesion is bothersome or cosmetically unacceptable, it can be removed by surgical excision or cryotherapy. | Treatment for large-cell acanthoma is usually not necessary, as the condition is benign and does not pose a risk for malignancy. However, if the lesion is bothersome or cosmetically unacceptable, it can be removed by surgical excision or cryotherapy. | ||
== See also == | == See also == | ||
* [[List of cutaneous conditions]] | * [[List of cutaneous conditions]] | ||
* [[Dermatology]] | * [[Dermatology]] | ||
* [[Skin lesion]] | * [[Skin lesion]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Skin conditions]] | [[Category:Skin conditions]] | ||
| Line 30: | Line 40: | ||
{{Dermatology-stub}} | {{Dermatology-stub}} | ||
{{Medicine-stub}} | {{Medicine-stub}} | ||
Latest revision as of 21:10, 6 April 2025
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| Large-cell acanthoma | |
|---|---|
 | |
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Skin lesion |
| Complications | |
| Onset | |
| Duration | |
| Types | N/A |
| Causes | Unknown |
| Risks | |
| Diagnosis | Skin biopsy |
| Differential diagnosis | Seborrheic keratosis, Actinic keratosis |
| Prevention | |
| Treatment | Cryotherapy, Laser therapy, Surgical excision |
| Medication | |
| Prognosis | |
| Frequency | |
| Deaths | |
Large-cell acanthoma is a benign skin lesion that is characterized by its large, pale-staining keratinocytes. It is a rare condition that is often mistaken for other skin conditions, such as actinic keratosis or squamous cell carcinoma.
History[edit]
Large-cell acanthoma was first described in 1968 by the dermatologist Robert Degos. It was initially thought to be a variant of seborrheic keratosis, but further studies have shown that it is a distinct entity.
Characteristics[edit]
Large-cell acanthoma typically presents as a solitary, well-demarcated, flat or slightly raised lesion. It is usually found on sun-exposed areas of the body, such as the face, neck, and arms. The lesion is often asymptomatic, but it may cause mild itching or discomfort. Histologically, large-cell acanthoma is characterized by an increased number of large, pale-staining keratinocytes in the epidermis. These cells are larger than the surrounding keratinocytes and have a clear or pale cytoplasm. The dermis underneath the lesion may show signs of solar elastosis, indicating chronic sun damage.
Diagnosis[edit]
The diagnosis of large-cell acanthoma is usually made based on the clinical appearance of the lesion and the histological findings. A skin biopsy may be performed to confirm the diagnosis and to rule out other skin conditions.
Treatment[edit]
Treatment for large-cell acanthoma is usually not necessary, as the condition is benign and does not pose a risk for malignancy. However, if the lesion is bothersome or cosmetically unacceptable, it can be removed by surgical excision or cryotherapy.
See also[edit]
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