Haff disease: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Haff disease | |||
| image = [[File:Vistula_Lagoon.jpg|250px]] | |||
| caption = Vistula Lagoon, a location associated with cases of Haff disease | |||
| field = [[Toxicology]] | |||
| symptoms = [[Rhabdomyolysis]], muscle pain, [[weakness]], [[brown urine]] | |||
| onset = 24 hours after consuming affected fish | |||
| duration = Variable | |||
| causes = Consumption of certain types of [[fish]] | |||
| risks = Eating fish from affected areas | |||
| diagnosis = Clinical evaluation, [[creatine kinase]] levels | |||
| differential = [[Myositis]], [[polymyositis]], [[trichinosis]] | |||
| treatment = Supportive care, [[hydration]], [[dialysis]] if necessary | |||
| prognosis = Generally good with treatment | |||
| frequency = Rare | |||
| deaths = Rare | |||
}} | |||
'''Haff disease''' is a rare syndrome of unexplained [[rhabdomyolysis]] following consumption of certain types of fish; it is caused by an unidentified toxin in the fish. | '''Haff disease''' is a rare syndrome of unexplained [[rhabdomyolysis]] following consumption of certain types of fish; it is caused by an unidentified toxin in the fish. | ||
== Symptoms == | == Symptoms == | ||
The primary symptom of Haff disease is [[rhabdomyolysis]], a condition in which skeletal muscle breaks down rapidly. Symptoms can be mild or severe and may include muscle stiffness, pain, and dark urine. Other symptoms may include nausea, vomiting, chest pain, and shortness of breath. | The primary symptom of Haff disease is [[rhabdomyolysis]], a condition in which skeletal muscle breaks down rapidly. Symptoms can be mild or severe and may include muscle stiffness, pain, and dark urine. Other symptoms may include nausea, vomiting, chest pain, and shortness of breath. | ||
== Causes == | == Causes == | ||
The exact cause of Haff disease is unknown, but it is believed to be caused by a toxin in certain types of fish. The disease has been associated with the consumption of buffalo fish, freshwater pompano, and several other species of fish. | The exact cause of Haff disease is unknown, but it is believed to be caused by a toxin in certain types of fish. The disease has been associated with the consumption of buffalo fish, freshwater pompano, and several other species of fish. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of Haff disease is based on the presence of rhabdomyolysis following the consumption of fish. Laboratory tests may show high levels of [[creatine kinase]] and [[myoglobin]] in the blood and urine. | Diagnosis of Haff disease is based on the presence of rhabdomyolysis following the consumption of fish. Laboratory tests may show high levels of [[creatine kinase]] and [[myoglobin]] in the blood and urine. | ||
== Treatment == | == Treatment == | ||
Treatment for Haff disease is primarily supportive and includes hydration to help flush the myoglobin out of the kidneys. In severe cases, hospitalization may be required. | Treatment for Haff disease is primarily supportive and includes hydration to help flush the myoglobin out of the kidneys. In severe cases, hospitalization may be required. | ||
== Prevention == | == Prevention == | ||
Prevention of Haff disease involves avoiding the consumption of fish species associated with the disease. | Prevention of Haff disease involves avoiding the consumption of fish species associated with the disease. | ||
== See also == | == See also == | ||
* [[Rhabdomyolysis]] | * [[Rhabdomyolysis]] | ||
| Line 21: | Line 33: | ||
* [[Buffalo fish]] | * [[Buffalo fish]] | ||
* [[Freshwater pompano]] | * [[Freshwater pompano]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Foodborne illnesses]] | [[Category:Foodborne illnesses]] | ||
[[Category:Toxic effects of substances chiefly nonmedicinal as to source]] | [[Category:Toxic effects of substances chiefly nonmedicinal as to source]] | ||
[[Category:Syndromes]] | [[Category:Syndromes]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 20:26, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Haff disease | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Rhabdomyolysis, muscle pain, weakness, brown urine |
| Complications | N/A |
| Onset | 24 hours after consuming affected fish |
| Duration | Variable |
| Types | N/A |
| Causes | Consumption of certain types of fish |
| Risks | Eating fish from affected areas |
| Diagnosis | Clinical evaluation, creatine kinase levels |
| Differential diagnosis | Myositis, polymyositis, trichinosis |
| Prevention | N/A |
| Treatment | Supportive care, hydration, dialysis if necessary |
| Medication | N/A |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | Rare |
Haff disease is a rare syndrome of unexplained rhabdomyolysis following consumption of certain types of fish; it is caused by an unidentified toxin in the fish.
Symptoms[edit]
The primary symptom of Haff disease is rhabdomyolysis, a condition in which skeletal muscle breaks down rapidly. Symptoms can be mild or severe and may include muscle stiffness, pain, and dark urine. Other symptoms may include nausea, vomiting, chest pain, and shortness of breath.
Causes[edit]
The exact cause of Haff disease is unknown, but it is believed to be caused by a toxin in certain types of fish. The disease has been associated with the consumption of buffalo fish, freshwater pompano, and several other species of fish.
Diagnosis[edit]
Diagnosis of Haff disease is based on the presence of rhabdomyolysis following the consumption of fish. Laboratory tests may show high levels of creatine kinase and myoglobin in the blood and urine.
Treatment[edit]
Treatment for Haff disease is primarily supportive and includes hydration to help flush the myoglobin out of the kidneys. In severe cases, hospitalization may be required.
Prevention[edit]
Prevention of Haff disease involves avoiding the consumption of fish species associated with the disease.
