Connective tissue nevus: Difference between revisions
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{{Infobox medical condition | |||
| name = Connective tissue nevus | |||
| image = [[File:SkinTumors-PA100988.jpg]] | |||
| caption = Connective tissue nevus on the skin | |||
| field = [[Dermatology]] | |||
| synonyms = Shagreen patch, collagenoma | |||
| symptoms = [[Skin]] lesions, [[nodule]]s, [[plaque (dermatology)|plaques]] | |||
| complications = [[Cosmetic]] concerns, potential association with [[tuberous sclerosis]] | |||
| onset = [[Childhood]] or [[adolescence]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| causes = [[Genetic disorder|Genetic]] factors, [[sporadic]] | |||
| risks = Family history of [[genetic syndromes]] | |||
| diagnosis = [[Clinical diagnosis|Clinical examination]], [[skin biopsy]] | |||
| differential = [[Dermatofibroma]], [[neurofibroma]], [[lipoma]] | |||
| treatment = [[Surgical excision]], [[laser therapy]] | |||
| prognosis = Generally [[benign]] | |||
| frequency = Rare | |||
}} | |||
{{DISPLAYTITLE:Connective Tissue Nevus}} | {{DISPLAYTITLE:Connective Tissue Nevus}} | ||
== Connective Tissue Nevus == | == Connective Tissue Nevus == | ||
[[File:SkinTumors-PA100988.jpg|thumb | [[File:SkinTumors-PA100988.jpg|left|thumb|A clinical image of a connective tissue nevus on the skin.]] | ||
A '''connective tissue nevus''' is a type of [[hamartoma]] that arises from the [[connective tissue]] of the [[skin]]. These lesions are characterized by an overgrowth of one or more components of the dermal connective tissue, such as [[collagen]], [[elastin]], or [[glycosaminoglycans]]. | A '''connective tissue nevus''' is a type of [[hamartoma]] that arises from the [[connective tissue]] of the [[skin]]. These lesions are characterized by an overgrowth of one or more components of the dermal connective tissue, such as [[collagen]], [[elastin]], or [[glycosaminoglycans]]. | ||
== Classification == | == Classification == | ||
Connective tissue nevi can be classified based on the predominant type of connective tissue involved: | Connective tissue nevi can be classified based on the predominant type of connective tissue involved: | ||
* '''Collagenous nevi''': These are the most common type and are characterized by an excess of [[collagen]] fibers. They are often referred to as "shagreen patches" when associated with [[tuberous sclerosis]]. | * '''Collagenous nevi''': These are the most common type and are characterized by an excess of [[collagen]] fibers. They are often referred to as "shagreen patches" when associated with [[tuberous sclerosis]]. | ||
* '''Elastin nevi''': These nevi show an increase in [[elastin]] fibers and are sometimes associated with conditions like [[pseudoxanthoma elasticum]]. | * '''Elastin nevi''': These nevi show an increase in [[elastin]] fibers and are sometimes associated with conditions like [[pseudoxanthoma elasticum]]. | ||
* '''Proteoglycan nevi''': These are less common and involve an increase in [[proteoglycans]] within the dermis. | * '''Proteoglycan nevi''': These are less common and involve an increase in [[proteoglycans]] within the dermis. | ||
== Clinical Presentation == | == Clinical Presentation == | ||
Connective tissue nevi typically present as firm, skin-colored or yellowish plaques or nodules. They can appear anywhere on the body but are most commonly found on the [[trunk]] and [[extremities]]. The lesions are usually asymptomatic but may be associated with other systemic conditions. | Connective tissue nevi typically present as firm, skin-colored or yellowish plaques or nodules. They can appear anywhere on the body but are most commonly found on the [[trunk]] and [[extremities]]. The lesions are usually asymptomatic but may be associated with other systemic conditions. | ||
== Associated Conditions == | == Associated Conditions == | ||
Connective tissue nevi can occur as isolated lesions or as part of a syndrome. Some of the syndromes associated with connective tissue nevi include: | Connective tissue nevi can occur as isolated lesions or as part of a syndrome. Some of the syndromes associated with connective tissue nevi include: | ||
* '''[[Tuberous sclerosis]]''': Characterized by the presence of shagreen patches, which are collagenous nevi. | * '''[[Tuberous sclerosis]]''': Characterized by the presence of shagreen patches, which are collagenous nevi. | ||
* '''[[Buschke-Ollendorff syndrome]]''': A rare genetic disorder characterized by the presence of elastin nevi and osteopoikilosis. | * '''[[Buschke-Ollendorff syndrome]]''': A rare genetic disorder characterized by the presence of elastin nevi and osteopoikilosis. | ||
* '''[[Proteus syndrome]]''': A complex disorder that can include connective tissue nevi among its many manifestations. | * '''[[Proteus syndrome]]''': A complex disorder that can include connective tissue nevi among its many manifestations. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of a connective tissue nevus is primarily clinical, based on the appearance of the lesions. A [[skin biopsy]] can be performed to confirm the diagnosis and to determine the predominant type of connective tissue involved. | The diagnosis of a connective tissue nevus is primarily clinical, based on the appearance of the lesions. A [[skin biopsy]] can be performed to confirm the diagnosis and to determine the predominant type of connective tissue involved. | ||
== Treatment == | == Treatment == | ||
Treatment is usually not necessary for isolated connective tissue nevi unless they cause cosmetic concerns or discomfort. In such cases, surgical excision or [[laser therapy]] may be considered. | Treatment is usually not necessary for isolated connective tissue nevi unless they cause cosmetic concerns or discomfort. In such cases, surgical excision or [[laser therapy]] may be considered. | ||
== See also == | |||
== | |||
* [[Hamartoma]] | * [[Hamartoma]] | ||
* [[Tuberous sclerosis]] | * [[Tuberous sclerosis]] | ||
* [[Pseudoxanthoma elasticum]] | * [[Pseudoxanthoma elasticum]] | ||
* [[Proteus syndrome]] | * [[Proteus syndrome]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Connective tissue]] | [[Category:Connective tissue]] | ||
[[Category:Skin conditions]] | [[Category:Skin conditions]] | ||
Latest revision as of 02:14, 5 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Connective tissue nevus | |
|---|---|
| |
| Synonyms | Shagreen patch, collagenoma |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Skin lesions, nodules, plaques |
| Complications | Cosmetic concerns, potential association with tuberous sclerosis |
| Onset | Childhood or adolescence |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic factors, sporadic |
| Risks | Family history of genetic syndromes |
| Diagnosis | Clinical examination, skin biopsy |
| Differential diagnosis | Dermatofibroma, neurofibroma, lipoma |
| Prevention | N/A |
| Treatment | Surgical excision, laser therapy |
| Medication | N/A |
| Prognosis | Generally benign |
| Frequency | Rare |
| Deaths | N/A |
Connective Tissue Nevus[edit]
A connective tissue nevus is a type of hamartoma that arises from the connective tissue of the skin. These lesions are characterized by an overgrowth of one or more components of the dermal connective tissue, such as collagen, elastin, or glycosaminoglycans.
Classification[edit]
Connective tissue nevi can be classified based on the predominant type of connective tissue involved:
- Collagenous nevi: These are the most common type and are characterized by an excess of collagen fibers. They are often referred to as "shagreen patches" when associated with tuberous sclerosis.
- Elastin nevi: These nevi show an increase in elastin fibers and are sometimes associated with conditions like pseudoxanthoma elasticum.
- Proteoglycan nevi: These are less common and involve an increase in proteoglycans within the dermis.
Clinical Presentation[edit]
Connective tissue nevi typically present as firm, skin-colored or yellowish plaques or nodules. They can appear anywhere on the body but are most commonly found on the trunk and extremities. The lesions are usually asymptomatic but may be associated with other systemic conditions.
Associated Conditions[edit]
Connective tissue nevi can occur as isolated lesions or as part of a syndrome. Some of the syndromes associated with connective tissue nevi include:
- Tuberous sclerosis: Characterized by the presence of shagreen patches, which are collagenous nevi.
- Buschke-Ollendorff syndrome: A rare genetic disorder characterized by the presence of elastin nevi and osteopoikilosis.
- Proteus syndrome: A complex disorder that can include connective tissue nevi among its many manifestations.
Diagnosis[edit]
The diagnosis of a connective tissue nevus is primarily clinical, based on the appearance of the lesions. A skin biopsy can be performed to confirm the diagnosis and to determine the predominant type of connective tissue involved.
Treatment[edit]
Treatment is usually not necessary for isolated connective tissue nevi unless they cause cosmetic concerns or discomfort. In such cases, surgical excision or laser therapy may be considered.
