Chromium toxicity

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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W8MD medical weight loss NYC and sleep center NYC

Chromium toxicity
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Dermatitis, ulceration, respiratory problems, kidney damage, liver damage
Complications	Cancer, allergic reactions
Onset	Varies depending on exposure level
Duration	Chronic or acute
Types	N/A
Causes	Exposure to hexavalent chromium compounds
Risks	Occupational exposure, environmental contamination
Diagnosis	Blood test, urine test, biopsy
Differential diagnosis	Heavy metal poisoning, allergic contact dermatitis
Prevention	Use of protective equipment, environmental regulations
Treatment	Removal from exposure, chelating agents, supportive care
Medication	N/A
Prognosis	Depends on level and duration of exposure
Frequency	More common in industrial settings
Deaths	N/A

Chromium Toxicity

Chromium on the periodic table

Chromium toxicity refers to the harmful effects of chromium compounds on living organisms. Chromium is a chemical element with the symbol Cr and atomic number 24. It is found in several oxidation states, but the most common are chromium(0), chromium(III), and chromium(VI). Chromium(III) is an essential nutrient in trace amounts, while chromium(VI) is highly toxic and carcinogenic.

Forms of Chromium

Chromium exists in several forms, but the most biologically significant are:

• Chromium(0): The metallic form, used in industrial applications such as stainless steel production.
• Chromium(III): Also known as trivalent chromium, it is an essential nutrient that helps in the metabolism of carbohydrates, lipids, and proteins.
• Chromium(VI): Also known as hexavalent chromium, it is a potent oxidizing agent and is highly toxic.

Sources of Exposure

Exposure to chromium can occur through various routes:

• Occupational exposure: Workers in industries such as electroplating, leather tanning, and stainless steel production are at risk of exposure to chromium compounds.
• Environmental exposure: Chromium can be released into the environment through industrial waste, leading to contamination of air, water, and soil.
• Dietary exposure: Chromium(III) is present in foods such as broccoli, liver, and whole grains, but chromium(VI) is not typically found in food.

Health Effects

The health effects of chromium exposure depend on the form and route of exposure:

• Chromium(III): Generally considered safe and necessary in small amounts, but excessive intake can lead to adverse effects.
• Chromium(VI): Known to cause skin irritation, ulceration, and allergic reactions. Inhalation can lead to respiratory problems, lung cancer, and other serious health issues.

Mechanism of Toxicity

Chromium(VI) compounds are highly soluble and can easily penetrate biological membranes. Once inside the cell, they are reduced to chromium(III), which can bind to cellular components, causing oxidative stress and DNA damage. This mechanism is responsible for the carcinogenic potential of chromium(VI).

Prevention and Treatment

Preventive measures include:

• Regulation and monitoring: Implementing strict industrial regulations to limit chromium emissions and exposure.
• Personal protective equipment (PPE): Use of gloves, masks, and protective clothing in occupational settings.

Treatment of chromium toxicity involves:

• Chelation therapy: Use of agents like EDTA to bind and remove chromium from the body.
• Supportive care: Managing symptoms and providing supportive treatment for affected individuals.

See also

• Chromium
• Heavy metal toxicity
• Occupational safety and health