Cholinergic crisis: Difference between revisions
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{{Infobox medical condition | |||
| name = Cholinergic crisis | |||
| synonyms = | |||
| field = [[Neurology]], [[Toxicology]] | |||
| symptoms = [[Muscle weakness]], [[fasciculations]], [[sweating]], [[salivation]], [[lacrimation]], [[diarrhea]], [[miosis]], [[bradycardia]], [[bronchospasm]], [[seizures]] | |||
| complications = [[Respiratory failure]], [[cardiac arrest]] | |||
| onset = Rapid | |||
| duration = Variable, depending on treatment | |||
| causes = [[Overdose]] of [[cholinesterase inhibitors]], [[organophosphate poisoning]] | |||
| risks = Use of [[acetylcholinesterase inhibitors]], exposure to [[organophosphates]] | |||
| diagnosis = Clinical evaluation, history of exposure | |||
| differential = [[Myasthenic crisis]], [[organophosphate poisoning]], [[botulism]] | |||
| prevention = Avoidance of excessive [[cholinesterase inhibitors]], proper handling of [[organophosphates]] | |||
| treatment = [[Atropine]], [[pralidoxime]], [[supportive care]] | |||
| medication = [[Atropine]], [[pralidoxime]] | |||
| prognosis = Variable, can be life-threatening if untreated | |||
| frequency = Rare | |||
}} | |||
== Cholinergic Crisis == | == Cholinergic Crisis == | ||
A cholinergic crisis is a medical condition characterized by overstimulation of the parasympathetic nervous system due to an excess of acetylcholine. This can lead to a range of symptoms affecting various bodily functions. | A cholinergic crisis is a medical condition characterized by overstimulation of the parasympathetic nervous system due to an excess of acetylcholine. This can lead to a range of symptoms affecting various bodily functions. | ||
=== Causes === | === Causes === | ||
Cholinergic crises can be caused by various factors, including: | Cholinergic crises can be caused by various factors, including: | ||
* Overdose of cholinergic medications such as acetylcholinesterase inhibitors | * Overdose of cholinergic medications such as acetylcholinesterase inhibitors | ||
* Exposure to certain toxins or chemicals that affect acetylcholine levels | * Exposure to certain toxins or chemicals that affect acetylcholine levels | ||
* Certain medical conditions that disrupt the normal balance of acetylcholine in the body | * Certain medical conditions that disrupt the normal balance of acetylcholine in the body | ||
=== Symptoms === | === Symptoms === | ||
Symptoms of a cholinergic crisis may include: | Symptoms of a cholinergic crisis may include: | ||
* Excessive salivation | * Excessive salivation | ||
* Sweating | * Sweating | ||
| Line 23: | Line 35: | ||
* Difficulty breathing | * Difficulty breathing | ||
* Bradycardia (slow heart rate) | * Bradycardia (slow heart rate) | ||
=== Diagnosis === | === Diagnosis === | ||
Diagnosing a cholinergic crisis involves a thorough medical history, physical examination, and possibly laboratory tests to assess acetylcholine levels in the body. | Diagnosing a cholinergic crisis involves a thorough medical history, physical examination, and possibly laboratory tests to assess acetylcholine levels in the body. | ||
=== Treatment === | === Treatment === | ||
Treatment of a cholinergic crisis typically involves: | Treatment of a cholinergic crisis typically involves: | ||
* Discontinuation of any cholinergic medications | * Discontinuation of any cholinergic medications | ||
* Supportive care to manage symptoms such as breathing difficulties and heart rate abnormalities | * Supportive care to manage symptoms such as breathing difficulties and heart rate abnormalities | ||
* Administration of antidotes such as atropine to counteract the effects of excess acetylcholine | * Administration of antidotes such as atropine to counteract the effects of excess acetylcholine | ||
=== Prevention === | === Prevention === | ||
Preventing a cholinergic crisis involves careful monitoring of medication dosages, avoiding exposure to toxins that affect acetylcholine levels, and managing underlying medical conditions that may contribute to the condition. | Preventing a cholinergic crisis involves careful monitoring of medication dosages, avoiding exposure to toxins that affect acetylcholine levels, and managing underlying medical conditions that may contribute to the condition. | ||
For more information on related topics, please refer to the following articles: | For more information on related topics, please refer to the following articles: | ||
* [[Acetylcholine]] | * [[Acetylcholine]] | ||
* [[Parasympathetic nervous system]] | * [[Parasympathetic nervous system]] | ||
* [[Acetylcholinesterase inhibitors]] | * [[Acetylcholinesterase inhibitors]] | ||
[[Category:Medical Conditions]] | [[Category:Medical Conditions]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
Latest revision as of 04:43, 4 April 2025
| Cholinergic crisis | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Muscle weakness, fasciculations, sweating, salivation, lacrimation, diarrhea, miosis, bradycardia, bronchospasm, seizures |
| Complications | Respiratory failure, cardiac arrest |
| Onset | Rapid |
| Duration | Variable, depending on treatment |
| Types | N/A |
| Causes | Overdose of cholinesterase inhibitors, organophosphate poisoning |
| Risks | Use of acetylcholinesterase inhibitors, exposure to organophosphates |
| Diagnosis | Clinical evaluation, history of exposure |
| Differential diagnosis | Myasthenic crisis, organophosphate poisoning, botulism |
| Prevention | Avoidance of excessive cholinesterase inhibitors, proper handling of organophosphates |
| Treatment | Atropine, pralidoxime, supportive care |
| Medication | Atropine, pralidoxime |
| Prognosis | Variable, can be life-threatening if untreated |
| Frequency | Rare |
| Deaths | N/A |
Cholinergic Crisis[edit]
A cholinergic crisis is a medical condition characterized by overstimulation of the parasympathetic nervous system due to an excess of acetylcholine. This can lead to a range of symptoms affecting various bodily functions.
Causes[edit]
Cholinergic crises can be caused by various factors, including:
- Overdose of cholinergic medications such as acetylcholinesterase inhibitors
- Exposure to certain toxins or chemicals that affect acetylcholine levels
- Certain medical conditions that disrupt the normal balance of acetylcholine in the body
Symptoms[edit]
Symptoms of a cholinergic crisis may include:
- Excessive salivation
- Sweating
- Nausea and vomiting
- Diarrhea
- Blurred vision
- Muscle weakness
- Difficulty breathing
- Bradycardia (slow heart rate)
Diagnosis[edit]
Diagnosing a cholinergic crisis involves a thorough medical history, physical examination, and possibly laboratory tests to assess acetylcholine levels in the body.
Treatment[edit]
Treatment of a cholinergic crisis typically involves:
- Discontinuation of any cholinergic medications
- Supportive care to manage symptoms such as breathing difficulties and heart rate abnormalities
- Administration of antidotes such as atropine to counteract the effects of excess acetylcholine
Prevention[edit]
Preventing a cholinergic crisis involves careful monitoring of medication dosages, avoiding exposure to toxins that affect acetylcholine levels, and managing underlying medical conditions that may contribute to the condition. For more information on related topics, please refer to the following articles:
