Glucagonoma: Difference between revisions
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{{Infobox medical condition | |||
| name = Glucagonoma | |||
| synonyms = | |||
| specialty = [[Endocrinology]] | |||
| symptoms = [[Diabetes mellitus]], [[necrolytic migratory erythema]], [[weight loss]], [[anemia]], [[diarrhea]] | |||
| complications = [[Deep vein thrombosis]], [[pulmonary embolism]] | |||
| onset = Middle age | |||
| duration = Chronic | |||
| causes = [[Pancreatic alpha cell tumor]] | |||
| risks = | |||
| diagnosis = [[Blood test]] for elevated [[glucagon]] levels, [[imaging studies]] | |||
| differential = [[Zollinger-Ellison syndrome]], [[VIPoma]], [[insulinoma]] | |||
| prevention = | |||
| treatment = [[Surgery]], [[somatostatin analogs]], [[chemotherapy]] | |||
| medication = [[Octreotide]], [[lanreotide]] | |||
| prognosis = Variable, depends on stage at diagnosis | |||
| frequency = Rare | |||
}} | |||
'''Glucagonoma''' is a rare [[tumor]] of the [[pancreatic alpha cells]] that results in an overproduction of the hormone [[glucagon]]. This condition is often associated with a syndrome of symptoms, known as [[Glucagonoma syndrome]]. | '''Glucagonoma''' is a rare [[tumor]] of the [[pancreatic alpha cells]] that results in an overproduction of the hormone [[glucagon]]. This condition is often associated with a syndrome of symptoms, known as [[Glucagonoma syndrome]]. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of Glucagonoma can vary widely and may include: | The symptoms of Glucagonoma can vary widely and may include: | ||
* [[Diabetes mellitus]]: High levels of glucagon can interfere with the body's ability to regulate blood sugar, leading to diabetes. | * [[Diabetes mellitus]]: High levels of glucagon can interfere with the body's ability to regulate blood sugar, leading to diabetes. | ||
* [[Necrolytic migratory erythema]] (NME): This is a skin condition characterized by red, blistering rashes that spread across the skin. | * [[Necrolytic migratory erythema]] (NME): This is a skin condition characterized by red, blistering rashes that spread across the skin. | ||
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* [[Anemia]]: This is a condition characterized by a lack of healthy red blood cells in the body. | * [[Anemia]]: This is a condition characterized by a lack of healthy red blood cells in the body. | ||
* [[Deep vein thrombosis]] (DVT): This is a blood clot that forms in a vein deep in the body, often in the leg. | * [[Deep vein thrombosis]] (DVT): This is a blood clot that forms in a vein deep in the body, often in the leg. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of Glucagonoma often involves a combination of blood tests, imaging studies, and sometimes a biopsy of the tumor. Blood tests can measure the level of glucagon in the body, while imaging studies such as CT scans or MRIs can help identify the location and size of the tumor. | Diagnosis of Glucagonoma often involves a combination of blood tests, imaging studies, and sometimes a biopsy of the tumor. Blood tests can measure the level of glucagon in the body, while imaging studies such as CT scans or MRIs can help identify the location and size of the tumor. | ||
== Treatment == | == Treatment == | ||
Treatment for Glucagonoma typically involves surgery to remove the tumor. In some cases, additional treatments such as chemotherapy or radiation therapy may be used. Medications may also be prescribed to help manage symptoms and control blood sugar levels. | Treatment for Glucagonoma typically involves surgery to remove the tumor. In some cases, additional treatments such as chemotherapy or radiation therapy may be used. Medications may also be prescribed to help manage symptoms and control blood sugar levels. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for Glucagonoma can vary depending on the size and location of the tumor, as well as the individual's overall health. Early detection and treatment can improve the prognosis. | The prognosis for Glucagonoma can vary depending on the size and location of the tumor, as well as the individual's overall health. Early detection and treatment can improve the prognosis. | ||
== See also == | == See also == | ||
* [[Pancreatic cancer]] | * [[Pancreatic cancer]] | ||
* [[Endocrine system]] | * [[Endocrine system]] | ||
* [[Hormone]] | * [[Hormone]] | ||
[[Category:Endocrine diseases]] | [[Category:Endocrine diseases]] | ||
[[Category:Pancreatic diseases]] | [[Category:Pancreatic diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 03:24, 4 April 2025
| Glucagonoma | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | Endocrinology |
| Symptoms | Diabetes mellitus, necrolytic migratory erythema, weight loss, anemia, diarrhea |
| Complications | Deep vein thrombosis, pulmonary embolism |
| Onset | Middle age |
| Duration | Chronic |
| Types | N/A |
| Causes | Pancreatic alpha cell tumor |
| Risks | |
| Diagnosis | Blood test for elevated glucagon levels, imaging studies |
| Differential diagnosis | Zollinger-Ellison syndrome, VIPoma, insulinoma |
| Prevention | |
| Treatment | Surgery, somatostatin analogs, chemotherapy |
| Medication | Octreotide, lanreotide |
| Prognosis | Variable, depends on stage at diagnosis |
| Frequency | Rare |
| Deaths | N/A |
Glucagonoma is a rare tumor of the pancreatic alpha cells that results in an overproduction of the hormone glucagon. This condition is often associated with a syndrome of symptoms, known as Glucagonoma syndrome.
Symptoms[edit]
The symptoms of Glucagonoma can vary widely and may include:
- Diabetes mellitus: High levels of glucagon can interfere with the body's ability to regulate blood sugar, leading to diabetes.
- Necrolytic migratory erythema (NME): This is a skin condition characterized by red, blistering rashes that spread across the skin.
- Weight loss: Unintentional weight loss is a common symptom of Glucagonoma.
- Anemia: This is a condition characterized by a lack of healthy red blood cells in the body.
- Deep vein thrombosis (DVT): This is a blood clot that forms in a vein deep in the body, often in the leg.
Diagnosis[edit]
Diagnosis of Glucagonoma often involves a combination of blood tests, imaging studies, and sometimes a biopsy of the tumor. Blood tests can measure the level of glucagon in the body, while imaging studies such as CT scans or MRIs can help identify the location and size of the tumor.
Treatment[edit]
Treatment for Glucagonoma typically involves surgery to remove the tumor. In some cases, additional treatments such as chemotherapy or radiation therapy may be used. Medications may also be prescribed to help manage symptoms and control blood sugar levels.
Prognosis[edit]
The prognosis for Glucagonoma can vary depending on the size and location of the tumor, as well as the individual's overall health. Early detection and treatment can improve the prognosis.
