Systematized epidermal nevus: Difference between revisions
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{{Infobox medical condition | |||
| name = Systematized epidermal nevus | |||
| synonyms = | |||
| specialty = [[Dermatology]] | |||
| symptoms = [[Hyperkeratosis]], [[papillomatous]] lesions | |||
| onset = [[Birth]] or early [[childhood]] | |||
| duration = [[Lifelong]] | |||
| causes = [[Genetic mutation]] | |||
| risks = | |||
| diagnosis = [[Clinical examination]], [[biopsy]] | |||
| differential = [[Linear epidermal nevus]], [[nevus sebaceous]], [[inflammatory linear verrucous epidermal nevus]] | |||
| treatment = [[Topical treatments]], [[laser therapy]], [[surgical excision]] | |||
| frequency = Rare | |||
}} | |||
'''Systematized epidermal nevus''' is a type of [[epidermal nevus]] that is characterized by the presence of multiple, widespread lesions that follow the lines of [[Blaschko's lines|Blaschko]]. These lesions are typically present at birth or develop in early childhood and can vary in size, shape, and color. | '''Systematized epidermal nevus''' is a type of [[epidermal nevus]] that is characterized by the presence of multiple, widespread lesions that follow the lines of [[Blaschko's lines|Blaschko]]. These lesions are typically present at birth or develop in early childhood and can vary in size, shape, and color. | ||
== Clinical Presentation == | == Clinical Presentation == | ||
Systematized epidermal nevi are often linear or whorled in appearance and can be found on any part of the body. They are usually hyperpigmented and may be raised or flat. The lesions can be isolated or part of a syndrome, such as [[epidermal nevus syndrome]]. | Systematized epidermal nevi are often linear or whorled in appearance and can be found on any part of the body. They are usually hyperpigmented and may be raised or flat. The lesions can be isolated or part of a syndrome, such as [[epidermal nevus syndrome]]. | ||
== Pathophysiology == | == Pathophysiology == | ||
The condition is caused by a postzygotic mutation in the [[keratinocyte]]s, leading to a mosaic pattern of skin involvement. The specific genetic mutations can vary, but they often involve genes related to the [[Ras/MAPK pathway]], which is important in cell growth and differentiation. | The condition is caused by a postzygotic mutation in the [[keratinocyte]]s, leading to a mosaic pattern of skin involvement. The specific genetic mutations can vary, but they often involve genes related to the [[Ras/MAPK pathway]], which is important in cell growth and differentiation. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis is primarily clinical, based on the characteristic appearance of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show hyperkeratosis, acanthosis, and papillomatosis. | Diagnosis is primarily clinical, based on the characteristic appearance of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show hyperkeratosis, acanthosis, and papillomatosis. | ||
== Treatment == | == Treatment == | ||
Treatment options for systematized epidermal nevus are limited and primarily focus on cosmetic improvement. Options include: | Treatment options for systematized epidermal nevus are limited and primarily focus on cosmetic improvement. Options include: | ||
* [[Laser therapy]] | * [[Laser therapy]] | ||
* [[Surgical excision]] | * [[Surgical excision]] | ||
* Topical treatments such as [[retinoids]] | * Topical treatments such as [[retinoids]] | ||
== Prognosis == | == Prognosis == | ||
The prognosis for individuals with systematized epidermal nevus is generally good, although the lesions are often persistent and may require ongoing management. In some cases, there may be an association with other systemic abnormalities, necessitating a multidisciplinary approach to care. | The prognosis for individuals with systematized epidermal nevus is generally good, although the lesions are often persistent and may require ongoing management. In some cases, there may be an association with other systemic abnormalities, necessitating a multidisciplinary approach to care. | ||
== Related Pages == | == Related Pages == | ||
* [[Epidermal nevus]] | * [[Epidermal nevus]] | ||
* [[Epidermal nevus syndrome]] | * [[Epidermal nevus syndrome]] | ||
* [[Blaschko's lines]] | * [[Blaschko's lines]] | ||
* [[Keratinocyte]] | * [[Keratinocyte]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Latest revision as of 00:43, 4 April 2025
| Systematized epidermal nevus | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | Dermatology |
| Symptoms | Hyperkeratosis, papillomatous lesions |
| Complications | N/A |
| Onset | Birth or early childhood |
| Duration | Lifelong |
| Types | N/A |
| Causes | Genetic mutation |
| Risks | |
| Diagnosis | Clinical examination, biopsy |
| Differential diagnosis | Linear epidermal nevus, nevus sebaceous, inflammatory linear verrucous epidermal nevus |
| Prevention | N/A |
| Treatment | Topical treatments, laser therapy, surgical excision |
| Medication | N/A |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | N/A |
Systematized epidermal nevus is a type of epidermal nevus that is characterized by the presence of multiple, widespread lesions that follow the lines of Blaschko. These lesions are typically present at birth or develop in early childhood and can vary in size, shape, and color.
Clinical Presentation[edit]
Systematized epidermal nevi are often linear or whorled in appearance and can be found on any part of the body. They are usually hyperpigmented and may be raised or flat. The lesions can be isolated or part of a syndrome, such as epidermal nevus syndrome.
Pathophysiology[edit]
The condition is caused by a postzygotic mutation in the keratinocytes, leading to a mosaic pattern of skin involvement. The specific genetic mutations can vary, but they often involve genes related to the Ras/MAPK pathway, which is important in cell growth and differentiation.
Diagnosis[edit]
Diagnosis is primarily clinical, based on the characteristic appearance of the lesions. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show hyperkeratosis, acanthosis, and papillomatosis.
Treatment[edit]
Treatment options for systematized epidermal nevus are limited and primarily focus on cosmetic improvement. Options include:
- Laser therapy
- Surgical excision
- Topical treatments such as retinoids
Prognosis[edit]
The prognosis for individuals with systematized epidermal nevus is generally good, although the lesions are often persistent and may require ongoing management. In some cases, there may be an association with other systemic abnormalities, necessitating a multidisciplinary approach to care.
