Neonatal lupus erythematosus: Difference between revisions
From WikiMD's Wellness Encyclopedia
No edit summary Tag: Manual revert |
CSV import |
||
| Line 1: | Line 1: | ||
{{Infobox medical condition | |||
| name = Neonatal lupus erythematosus | |||
| synonyms = NLE | |||
| field = [[Rheumatology]], [[Pediatrics]] | |||
| symptoms = [[Rash]], [[congenital heart block]], [[liver dysfunction]], [[hematological abnormalities]] | |||
| complications = [[Congenital heart block]] | |||
| onset = [[Neonatal]] | |||
| duration = Varies, rash typically resolves within 6 months | |||
| causes = [[Transplacental passage]] of maternal [[autoantibodies]] | |||
| risks = Maternal [[systemic lupus erythematosus]], [[Sjogren's syndrome]] | |||
| diagnosis = Clinical evaluation, [[serology]] for maternal autoantibodies | |||
| differential = [[Erythema toxicum neonatorum]], [[seborrheic dermatitis]], [[atopic dermatitis]] | |||
| treatment = Supportive care, [[corticosteroids]] for severe cases | |||
| prognosis = Generally good, except for cases with congenital heart block | |||
| frequency = Rare | |||
}} | |||
'''Neonatal lupus erythematosus''' (NLE) is a rare autoimmune disease that affects newborns. It is caused by the transplacental passage of maternal autoantibodies to the fetus. The most common clinical manifestations are skin rash, heart block, and hematological abnormalities. | '''Neonatal lupus erythematosus''' (NLE) is a rare autoimmune disease that affects newborns. It is caused by the transplacental passage of maternal autoantibodies to the fetus. The most common clinical manifestations are skin rash, heart block, and hematological abnormalities. | ||
==Etiology== | ==Etiology== | ||
NLE is caused by the passage of maternal autoantibodies, specifically [[anti-Ro/SSA]] and [[anti-La/SSB]], across the placenta to the fetus. These antibodies are found in mothers with autoimmune diseases such as [[Systemic lupus erythematosus|SLE]] and [[Sjögren's syndrome]]. However, some mothers of infants with NLE do not have any symptoms of these diseases. | |||
NLE is caused by the passage of maternal autoantibodies, specifically [[anti-Ro/SSA]] and [[anti-La/SSB]], across the placenta to the fetus. These antibodies are found in mothers with autoimmune diseases such as [[Systemic lupus erythematosus|SLE]] and [[ | |||
==Clinical Manifestations== | ==Clinical Manifestations== | ||
The most common clinical manifestations of NLE are: | The most common clinical manifestations of NLE are: | ||
* [[Skin rash]]: This is often the first sign of NLE. It usually appears within the first few weeks of life and resolves within six months. The rash is typically annular and erythematous, and is most commonly found on the face and scalp. | * [[Skin rash]]: This is often the first sign of NLE. It usually appears within the first few weeks of life and resolves within six months. The rash is typically annular and erythematous, and is most commonly found on the face and scalp. | ||
* [[Heart block]]: This is a serious complication of NLE and can lead to death. It is usually detected in utero and is irreversible. | * [[Heart block]]: This is a serious complication of NLE and can lead to death. It is usually detected in utero and is irreversible. | ||
* Hematological abnormalities: These can include [[thrombocytopenia]], [[neutropenia]], and [[anemia]]. | * Hematological abnormalities: These can include [[thrombocytopenia]], [[neutropenia]], and [[anemia]]. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of NLE is based on clinical findings and the presence of maternal autoantibodies. Skin biopsy can be used to confirm the diagnosis. | The diagnosis of NLE is based on clinical findings and the presence of maternal autoantibodies. Skin biopsy can be used to confirm the diagnosis. | ||
==Treatment== | ==Treatment== | ||
There is no specific treatment for NLE. Management is supportive and includes sun protection for the skin rash and pacemaker implantation for heart block. | There is no specific treatment for NLE. Management is supportive and includes sun protection for the skin rash and pacemaker implantation for heart block. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for NLE is generally good. The skin rash and hematological abnormalities usually resolve within six months. However, heart block is a serious complication and can lead to death. | The prognosis for NLE is generally good. The skin rash and hematological abnormalities usually resolve within six months. However, heart block is a serious complication and can lead to death. | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Neonatology]] | [[Category:Neonatology]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 23:23, 3 April 2025
| Neonatal lupus erythematosus | |
|---|---|
| Synonyms | NLE |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Rash, congenital heart block, liver dysfunction, hematological abnormalities |
| Complications | Congenital heart block |
| Onset | Neonatal |
| Duration | Varies, rash typically resolves within 6 months |
| Types | N/A |
| Causes | Transplacental passage of maternal autoantibodies |
| Risks | Maternal systemic lupus erythematosus, Sjogren's syndrome |
| Diagnosis | Clinical evaluation, serology for maternal autoantibodies |
| Differential diagnosis | Erythema toxicum neonatorum, seborrheic dermatitis, atopic dermatitis |
| Prevention | N/A |
| Treatment | Supportive care, corticosteroids for severe cases |
| Medication | N/A |
| Prognosis | Generally good, except for cases with congenital heart block |
| Frequency | Rare |
| Deaths | N/A |
Neonatal lupus erythematosus (NLE) is a rare autoimmune disease that affects newborns. It is caused by the transplacental passage of maternal autoantibodies to the fetus. The most common clinical manifestations are skin rash, heart block, and hematological abnormalities.
Etiology[edit]
NLE is caused by the passage of maternal autoantibodies, specifically anti-Ro/SSA and anti-La/SSB, across the placenta to the fetus. These antibodies are found in mothers with autoimmune diseases such as SLE and Sjögren's syndrome. However, some mothers of infants with NLE do not have any symptoms of these diseases.
Clinical Manifestations[edit]
The most common clinical manifestations of NLE are:
- Skin rash: This is often the first sign of NLE. It usually appears within the first few weeks of life and resolves within six months. The rash is typically annular and erythematous, and is most commonly found on the face and scalp.
- Heart block: This is a serious complication of NLE and can lead to death. It is usually detected in utero and is irreversible.
- Hematological abnormalities: These can include thrombocytopenia, neutropenia, and anemia.
Diagnosis[edit]
The diagnosis of NLE is based on clinical findings and the presence of maternal autoantibodies. Skin biopsy can be used to confirm the diagnosis.
Treatment[edit]
There is no specific treatment for NLE. Management is supportive and includes sun protection for the skin rash and pacemaker implantation for heart block.
Prognosis[edit]
The prognosis for NLE is generally good. The skin rash and hematological abnormalities usually resolve within six months. However, heart block is a serious complication and can lead to death.
