Diazinon: Difference between revisions
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'''Diazinon''' is an organophosphate insecticide that | == Diazinon == | ||
[[File:Diazinon-Structural_Formula_V1.svg|Diazinon Structural Formula|thumb|right]] | |||
'''Diazinon''' is an organophosphate insecticide that was widely used in agriculture and for household pest control. It is known for its effectiveness against a variety of insects, including cockroaches, ants, and fleas. However, due to concerns about its environmental impact and potential health risks, its use has been restricted or banned in many countries. | |||
== Chemical Properties == | |||
Diazinon is a colorless to dark brown liquid with a faint ester-like odor. It is soluble in organic solvents but has low solubility in water. The chemical formula for diazinon is C<sub>12</sub>H<sub>21</sub>N<sub>2</sub>O<sub>3</sub>PS, and its molecular weight is 304.35 g/mol. | |||
[[File:Diazinon-Molecule-3D-balls-by-AHRLS.png|Diazinon Molecule 3D Balls|thumb|left]] | |||
== Mechanism of Action == | |||
Diazinon functions by inhibiting the enzyme acetylcholinesterase, which is essential for nerve function in insects. This inhibition leads to an accumulation of acetylcholine at nerve synapses, causing continuous nerve impulses, paralysis, and eventually death of the insect. | |||
Diazinon | |||
== | == Biotransformation == | ||
[[File:Diazinon_Biotransformation_Mechanism.pdf|Diazinon Biotransformation Mechanism|thumb|right]] | |||
Diazinon | |||
In the environment and within organisms, diazinon undergoes biotransformation. It is metabolized primarily in the liver by cytochrome P450 enzymes to form diazoxon, a more potent acetylcholinesterase inhibitor. Further metabolism leads to less toxic compounds that are excreted from the body. | |||
In | |||
== | == Environmental Impact == | ||
Diazinon is known to be toxic to birds, fish, and aquatic invertebrates. Its use has been associated with declines in bird populations and contamination of water bodies. Due to its persistence in the environment and potential to bioaccumulate, diazinon poses significant ecological risks. | |||
== Human Health Effects == | |||
Exposure to diazinon can occur through inhalation, ingestion, or dermal contact. Acute exposure can lead to symptoms such as headache, dizziness, weakness, and nausea. Chronic exposure may result in more severe neurological effects. Due to these health concerns, regulatory agencies have imposed restrictions on its use. | |||
== Regulatory Status == | |||
In the United States, the Environmental Protection Agency (EPA) has phased out residential uses of diazinon. Agricultural uses are still permitted under strict regulations. In the European Union, diazinon is not approved for use. | |||
== Related Pages == | |||
* [[Organophosphate]] | * [[Organophosphate]] | ||
* [[ | * [[Insecticide]] | ||
* [[Acetylcholinesterase | * [[Acetylcholinesterase]] | ||
* [[ | * [[Pesticide regulation]] | ||
[[Category: | [[Category:Organophosphate insecticides]] | ||
[[Category:Environmental impact of pesticides]] | |||
[[Category:Environmental | [[Category:Neurotoxins]] | ||
[[Category: | |||
Latest revision as of 11:37, 23 March 2025
Diazinon[edit]
Diazinon is an organophosphate insecticide that was widely used in agriculture and for household pest control. It is known for its effectiveness against a variety of insects, including cockroaches, ants, and fleas. However, due to concerns about its environmental impact and potential health risks, its use has been restricted or banned in many countries.
Chemical Properties[edit]
Diazinon is a colorless to dark brown liquid with a faint ester-like odor. It is soluble in organic solvents but has low solubility in water. The chemical formula for diazinon is C12H21N2O3PS, and its molecular weight is 304.35 g/mol.
Mechanism of Action[edit]
Diazinon functions by inhibiting the enzyme acetylcholinesterase, which is essential for nerve function in insects. This inhibition leads to an accumulation of acetylcholine at nerve synapses, causing continuous nerve impulses, paralysis, and eventually death of the insect.
Biotransformation[edit]
File:Diazinon Biotransformation Mechanism.pdf
In the environment and within organisms, diazinon undergoes biotransformation. It is metabolized primarily in the liver by cytochrome P450 enzymes to form diazoxon, a more potent acetylcholinesterase inhibitor. Further metabolism leads to less toxic compounds that are excreted from the body.
Environmental Impact[edit]
Diazinon is known to be toxic to birds, fish, and aquatic invertebrates. Its use has been associated with declines in bird populations and contamination of water bodies. Due to its persistence in the environment and potential to bioaccumulate, diazinon poses significant ecological risks.
Human Health Effects[edit]
Exposure to diazinon can occur through inhalation, ingestion, or dermal contact. Acute exposure can lead to symptoms such as headache, dizziness, weakness, and nausea. Chronic exposure may result in more severe neurological effects. Due to these health concerns, regulatory agencies have imposed restrictions on its use.
Regulatory Status[edit]
In the United States, the Environmental Protection Agency (EPA) has phased out residential uses of diazinon. Agricultural uses are still permitted under strict regulations. In the European Union, diazinon is not approved for use.
