Mebanazine: Difference between revisions
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{{Short description|A monoamine oxidase inhibitor used as an antidepressant}} | |||
[[File:Mebanazine_structure.svg|thumb|right|Chemical structure of Mebanazine]] | |||
Mebanazine was | '''Mebanazine''' is a [[monoamine oxidase inhibitor]] (MAOI) that was used as an [[antidepressant]] in the treatment of [[depression]]. It belongs to the class of [[hydrazine]] derivatives and functions by inhibiting the activity of the enzyme [[monoamine oxidase]], which leads to an increase in the levels of [[neurotransmitters]] such as [[serotonin]], [[norepinephrine]], and [[dopamine]] in the brain. | ||
== Pharmacology == | ==Pharmacology== | ||
Mebanazine works by irreversibly binding to the monoamine oxidase enzyme, thereby preventing the breakdown of monoamine neurotransmitters. This results in increased concentrations of these neurotransmitters in the synaptic cleft, which is thought to contribute to its antidepressant effects. The inhibition of monoamine oxidase can lead to increased levels of [[tyramine]], a naturally occurring monoamine compound, which can cause hypertensive crises if dietary restrictions are not followed. | |||
Mebanazine | ==Clinical Use== | ||
Mebanazine was primarily used in the treatment of major depressive disorder, particularly in patients who did not respond to other types of antidepressants. Due to its potential for serious side effects and interactions with certain foods and medications, its use has declined with the development of newer antidepressants that have more favorable safety profiles. | |||
== | ==Side Effects== | ||
Common side effects of Mebanazine include dizziness, dry mouth, insomnia, and weight gain. More serious side effects can include hypertensive crisis, especially when taken with foods high in tyramine, such as aged cheeses and cured meats. Patients taking Mebanazine were advised to adhere to a strict diet to avoid these interactions. | |||
Mebanazine has been | ==Discontinuation== | ||
The use of Mebanazine has largely been discontinued in favor of newer antidepressants such as [[selective serotonin reuptake inhibitors]] (SSRIs) and [[serotonin-norepinephrine reuptake inhibitors]] (SNRIs), which have fewer dietary restrictions and a more favorable side effect profile. | |||
== | ==Related pages== | ||
* [[Monoamine oxidase inhibitor]] | |||
* [[Antidepressant]] | |||
* [[Depression (mood)]] | |||
* [[Selective serotonin reuptake inhibitor]] | |||
[[Category:Antidepressants]] | |||
[[Category:Monoamine oxidase inhibitors]] | |||
[[Category:Hydrazines]] | |||
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Latest revision as of 10:58, 23 March 2025
A monoamine oxidase inhibitor used as an antidepressant
Mebanazine is a monoamine oxidase inhibitor (MAOI) that was used as an antidepressant in the treatment of depression. It belongs to the class of hydrazine derivatives and functions by inhibiting the activity of the enzyme monoamine oxidase, which leads to an increase in the levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain.
Pharmacology[edit]
Mebanazine works by irreversibly binding to the monoamine oxidase enzyme, thereby preventing the breakdown of monoamine neurotransmitters. This results in increased concentrations of these neurotransmitters in the synaptic cleft, which is thought to contribute to its antidepressant effects. The inhibition of monoamine oxidase can lead to increased levels of tyramine, a naturally occurring monoamine compound, which can cause hypertensive crises if dietary restrictions are not followed.
Clinical Use[edit]
Mebanazine was primarily used in the treatment of major depressive disorder, particularly in patients who did not respond to other types of antidepressants. Due to its potential for serious side effects and interactions with certain foods and medications, its use has declined with the development of newer antidepressants that have more favorable safety profiles.
Side Effects[edit]
Common side effects of Mebanazine include dizziness, dry mouth, insomnia, and weight gain. More serious side effects can include hypertensive crisis, especially when taken with foods high in tyramine, such as aged cheeses and cured meats. Patients taking Mebanazine were advised to adhere to a strict diet to avoid these interactions.
Discontinuation[edit]
The use of Mebanazine has largely been discontinued in favor of newer antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), which have fewer dietary restrictions and a more favorable side effect profile.
