Neuropeptide Y receptor

Neuropeptide Y receptor is a class of G protein-coupled receptors that are activated by the neuropeptide Y and peptide YY. The human genes encoding the neuropeptide Y receptors are the NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R.

Function

Neuropeptide Y receptors are found in the brain and autonomic nervous system where they regulate a variety of physiological functions including feeding behavior, energy balance, and circadian rhythm. They are also involved in the regulation of mood and anxiety.

Types

There are several types of neuropeptide Y receptors, each with its own specific function and distribution in the body.

• NPY1R - This receptor is found in the brain and is involved in the regulation of feeding behavior and energy balance.
• NPY2R - This receptor is found in the brain and peripheral tissues and is involved in the regulation of blood pressure and circadian rhythm.
• NPY4R - This receptor is found in the brain and is involved in the regulation of mood and anxiety.
• NPY5R - This receptor is found in the brain and is involved in the regulation of feeding behavior and energy balance.
• NPY6R - This receptor is found in the peripheral tissues and is involved in the regulation of blood pressure.

Clinical significance

Alterations in the function of neuropeptide Y receptors have been implicated in a variety of diseases including obesity, depression, and anxiety disorders. Drugs that target these receptors may have therapeutic potential for these conditions.

See also

• Neuropeptide Y
• G protein-coupled receptor
• Peptide YY

References

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