Intraneural perineurioma

An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.

"Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis."<ref>,

 Intraneural perineurioma: a systematic review with illustrative cases, 
 Archives of Pathology & Laboratory Medicine, 
 2007,
 Vol. 131(Issue: 9),
 pp. 1382–92,
 DOI: [1382:IPASRW2.0.CO;2 10.1043/1543-2165(2007)131[1382:IPASRW]2.0.CO;2],
 PMID: 17824794,</ref>

Further reading

• ,

 Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm, 
 Archives of Pathology & Laboratory Medicine, 
 2007,
 Vol. 131(Issue: 4),
 pp. 625–36,
 DOI: [625:PADAUP2.0.CO;2 10.1043/1543-2165(2007)131[625:PADAUP]2.0.CO;2],
 PMID: 17425397,

• ,

 Intraneural reticular perineurioma of the hypoglossal nerve., 
 Head Neck., 
 2009,
 Vol. 31(Issue: 6),
 pp. 833–7,
 DOI: 10.1002/hed.20965,
 PMID: 18972430,

• ,

 Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique, 
 Arch Plast Surg, 
 2014,
 Vol. 41(Issue: 3),
 pp. 296–9,
 DOI: 10.5999/aps.2014.41.3.296,
 PMID: 24883285,
 PMC: 4037780,

• ,

 Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22, 
 Am J Clin Pathol, 
 1995,
 Vol. 103(Issue: 6),
 pp. 696–704,
 DOI: 10.1093/ajcp/103.6.696,
 PMID: 7785653,

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