Ellison

Ellison is a medical condition characterized by the presence of multiple gastrointestinal ulcers and hypergastrinemia. It is also known as the Zollinger-Ellison Syndrome (ZES). This condition is rare and is often associated with a tumor or gastrinoma in the pancreas or duodenum.

Symptoms

The symptoms of Ellison syndrome can vary greatly from person to person. However, the most common symptoms include:

• Abdominal pain
• Diarrhea
• Nausea and vomiting
• Weight loss
• Gastroesophageal reflux disease (GERD)

Causes

Ellison syndrome is caused by the presence of one or more gastrinomas in the pancreas or duodenum. These tumors produce excessive amounts of the hormone gastrin, which stimulates the production of gastric acid in the stomach. This leads to the formation of multiple ulcers in the gastrointestinal tract.

Diagnosis

The diagnosis of Ellison syndrome is typically made through a combination of medical history, physical examination, and laboratory tests. These tests may include:

• Blood tests to measure levels of gastrin
• Endoscopy to visualize the gastrointestinal tract
• Imaging studies such as CT scan or MRI to identify the presence of tumors

Treatment

The treatment of Ellison syndrome primarily involves managing the symptoms and removing the gastrinoma(s). This may involve:

• Medication to reduce the production of gastric acid
• Surgery to remove the gastrinoma(s)
• Chemotherapy or radiation therapy for tumors that cannot be surgically removed

Prognosis

The prognosis for individuals with Ellison syndrome can vary depending on the size and location of the gastrinoma(s), as well as the individual's overall health. However, with appropriate treatment, many individuals with this condition can lead a normal life.

See also

• Gastrinoma
• Gastrointestinal ulcer
• Hypergastrinemia

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