IL-11

IL-11 is a protein that in humans is encoded by the IL11 gene. IL-11 is a member of the interleukin family, a group of cytokines that are important in cell-to-cell communication in immune responses and during hematopoiesis.

Function

IL-11 is produced by stromal cells in the bone marrow and thymus. It functions in many hematopoietic processes, including the stimulation of megakaryocyte maturation and platelet production. IL-11 also has non-hematopoietic functions, such as playing a role in embryo implantation and the function of the gastrointestinal tract.

Clinical significance

IL-11 has been used therapeutically in the treatment of thrombocytopenia following chemotherapy for cancer. It is also being investigated for its potential to treat inflammatory diseases such as rheumatoid arthritis and Crohn's disease.

See also

• Interleukin 11 receptor, alpha subunit
• Interleukin 11 receptor, beta subunit

References

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External links

• IL-11 at WikiMD

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