TAS1R3

TAS1R3

TAS1R3 is a protein that in humans is encoded by the TAS1R3 gene. It is a member of the Taste receptor family, specifically the sweet taste receptor subfamily. This protein is involved in the perception of sweet taste and is expressed in various tissues, including the tongue, intestine, and brain.

Function

TAS1R3 is a G protein-coupled receptor that functions as a taste receptor, specifically for sweet tastes. It forms a heterodimer with either TAS1R2 or TAS1R1 to recognize a wide range of sweet substances, including sugar, artificial sweeteners, and some amino acids. The receptor activates a signal transduction pathway that ultimately leads to the perception of sweetness.

Clinical significance

Mutations in the TAS1R3 gene have been associated with differences in sweet taste perception and preference. Some studies have suggested a link between TAS1R3 and obesity, as individuals with certain TAS1R3 variants may have a higher preference for sweet foods. Additionally, TAS1R3 has been implicated in the regulation of glucose homeostasis and insulin secretion, suggesting a potential role in diabetes.

See also

• Taste receptor
• G protein-coupled receptor
• TAS1R2
• TAS1R1

References

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External links

• TAS1R3 at the National Center for Biotechnology Information

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