Pyostomatitis vegetans

Pyostomatitis vegetans is a rare, chronic, inflammatory condition, often associated with inflammatory bowel disease (IBD), particularly ulcerative colitis and, to a lesser extent, Crohn's disease. It is characterized by multiple, small, yellowish-white, pustular eruptions and vegetating plaques in the oral and occasionally genital mucosa.

Clinical Presentation

Patients with pyostomatitis vegetans often present with painful, recurrent, oral or genital ulcers. The oral lesions are typically located on the gingiva, buccal mucosa, lips, and tongue. The lesions are often accompanied by a foul-smelling breath and may interfere with eating and speaking.

Diagnosis

The diagnosis of pyostomatitis vegetans is based on the clinical presentation and histopathological findings. The histopathological examination typically shows acanthosis, intraepithelial abscesses, and eosinophilic infiltration. Direct immunofluorescence is usually negative.

Treatment

The treatment of pyostomatitis vegetans is primarily aimed at controlling the underlying IBD. Topical corticosteroids are often used to manage the oral lesions. In severe cases, systemic corticosteroids, dapsone, or other immunosuppressive agents may be required.

Prognosis

The prognosis of pyostomatitis vegetans is generally good with appropriate treatment. However, the condition tends to recur, particularly in patients with poorly controlled IBD.

See Also

• Inflammatory bowel disease
• Ulcerative colitis
• Crohn's disease

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