IL-3

IL-3 is a type of interleukin that is produced by T cells following cell activation by antigens. IL-3 is capable of supporting the growth and differentiation of T cells, B cells, mast cells, eosinophils, megakaryocytes, and granulocytes. In the immune system, IL-3 tends to be produced by T cells and mast cells.

Function

IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with other factors such as IL-7, into lymphoid progenitor cells. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response.

Clinical Significance

IL-3 has been associated with several autoimmune diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis. It is also involved in various biological processes, including allergy, asthma, and cancer.

See Also

• Interleukin
• T cells
• B cells
• Mast cells
• Eosinophils
• Megakaryocytes
• Granulocytes
• Hematopoietic stem cells
• Myeloid
• Lymphoid
• Autoimmune diseases
• Rheumatoid arthritis
• Psoriasis
• Multiple sclerosis
• Allergy
• Asthma
• Cancer

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