IRAK3

IRAK3 (Interleukin-1 receptor-associated kinase 3), also known as IRAK-M, is a protein that in humans is encoded by the IRAK3 gene. It is a member of the Interleukin-1 receptor-associated kinase protein family. These kinases are important mediators in the signal transduction of Toll-like receptor (TLRs) and Interleukin-1 receptor (IL1R) signaling pathways.

Function

IRAK3 is unique among the IRAK proteins, as it is an inhibitor of the Toll-like receptor signaling pathway, which is responsible for the innate immune response to microbial pathogens. It is thought to control inflammatory responses and prevent endotoxin tolerance.

Clinical significance

Mutations in the IRAK3 gene have been associated with susceptibility to asthma related traits type 6 (ASRT6). ASRT6 is a form of asthma that is triggered by substances such as pollen, dust mites, and animal dander.

See also

• Interleukin-1 receptor-associated kinase
• Toll-like receptor

References

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External links

• IRAK3 at the National Center for Biotechnology Information

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