IRAK2

IRAK2 or Interleukin-1 receptor-associated kinase 2 is a protein that in humans is encoded by the IRAK2 gene. It is a member of the Interleukin-1 receptor-associated kinase protein family. These kinases are important mediators in the signal transduction of Toll-like receptor (TLRs) and Interleukin-1 receptor (IL1R) signaling pathways.

Function

IRAK2 is a kinase associated with the Interleukin-1 receptor (IL1R). After the IL1R is stimulated by interleukin-1, IRAK2 is recruited to the IL1R through its interaction with the IL1R-associated kinase IRAK1. Once recruited, IRAK2 is phosphorylated by IRAK1, leading to its activation and ability to phosphorylate downstream targets.

Clinical significance

Alterations in the function of IRAK2 have been associated with several diseases, including cancer, autoimmune diseases, and inflammatory diseases. In particular, overexpression of IRAK2 has been observed in several types of cancer, suggesting a potential role in tumorigenesis.

See also

• Interleukin-1 receptor-associated kinase
• Interleukin-1 receptor
• Interleukin-1

References

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External links

• IRAK2 at the National Center for Biotechnology Information

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