GRIA4

GRIA4 or Glutamate Ionotropic Receptor AMPA Type Subunit 4 is a protein that in humans is encoded by the GRIA4 gene. It is a subunit of AMPA receptors, which are ionotropic glutamate receptors that mediate fast synaptic transmission in the central nervous system.

Function

The protein encoded by the GRIA4 gene is a subunit of an AMPA receptor. These receptors are ligand-gated ion channels that play a key role in fast excitatory synaptic transmission in the central nervous system. The receptors are assembled as a tetramer, with each subunit contributing to the pore of the ion channel.

Clinical Significance

Mutations in the GRIA4 gene have been associated with mental health disorders such as schizophrenia and bipolar disorder. Further research is needed to fully understand the role of GRIA4 in these conditions.

Structure

The GRIA4 protein is a transmembrane protein, meaning it spans the membrane of the cell. It has an extracellular N-terminus, which is the site of ligand binding, and an intracellular C-terminus, which is involved in regulating the receptor's function.

See Also

• AMPA receptor
• Glutamate receptor
• Schizophrenia
• Bipolar disorder

References

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