GDF3

GDF3 (Growth Differentiation Factor 3) is a protein that in humans is encoded by the GDF3 gene. It is a member of the TGF-beta superfamily of growth and differentiation factors.

Function

GDF3 is a secreted ligand of the TGF-beta (Transforming Growth Factor-beta) family, which has important roles in the formation of the embryo and in adult tissue homeostasis. It is expressed in various tissues, with high levels in the placenta and lower levels in the kidney and pancreas.

Clinical significance

Mutations in the GDF3 gene have been associated with various diseases, including cancer, diabetes, and obesity. It has also been implicated in the development of congenital heart defects and eye diseases.

Research

Research into GDF3 has focused on its role in stem cell differentiation and regenerative medicine. It has been found to be a key regulator of pluripotency in embryonic stem cells.

See also

• Growth differentiation factor
• TGF-beta superfamily

References

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External links

• GDF3 at the US National Library of Medicine Medical Subject Headings (MeSH)

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