Carboxylate transporter

Carboxylate transporter is a type of protein that facilitates the transport of carboxylate ions across biological membranes. These proteins are integral to many biological processes, including metabolism, cell signaling, and homeostasis.

Function

Carboxylate transporters are responsible for the movement of carboxylate ions across the cell membrane. This process is essential for maintaining the pH balance within the cell and for the transport of various metabolites.

Types

There are several types of carboxylate transporters, each with a specific function and location within the cell. These include:

• Monocarboxylate transporters: These transporters are responsible for the transport of monocarboxylates such as lactate, pyruvate, and ketone bodies.
• Dicarboxylate transporters: These transporters facilitate the transport of dicarboxylates such as succinate and malate.
• Tricarboxylate transporters: These transporters are involved in the transport of tricarboxylates such as citrate.

Clinical significance

Alterations in the function of carboxylate transporters can lead to various health conditions. For example, mutations in the genes encoding monocarboxylate transporters can result in lactic acidosis, a condition characterized by an excess of lactate in the body. Similarly, defects in dicarboxylate transporters can lead to metabolic disorders such as Krebs cycle disorders.

See also

• Transport protein
• Ion transport
• Cell membrane

References

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