CD155

CD155, also known as the poliovirus receptor or PVR, is a protein that in humans is encoded by the CD155 gene. It is a member of the immunoglobulin superfamily and mediates cell adhesion with other cells. CD155 is also a receptor for poliovirus in humans, hence its name.

Function

CD155 is a transmembrane protein that is part of the immunoglobulin superfamily. It is involved in cell adhesion and in the immune response. CD155 is also a receptor for poliovirus, the virus that causes polio. It is expressed in many tissues including the central nervous system, where poliovirus replication occurs.

Clinical significance

CD155 has been found to be overexpressed in several types of cancer, including lung cancer, breast cancer, and colorectal cancer. This overexpression has been associated with increased tumor growth and metastasis. CD155 is also a target for several immunotherapies that aim to boost the immune system's ability to fight cancer.

See also

• Cluster of differentiation
• Immunoglobulin superfamily
• Polio

References

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External links

• CD155 at the US National Library of Medicine Medical Subject Headings (MeSH)

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