CD44

CD44 is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 is expressed in a large number of mammalian cell types.

Function

CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 is also involved in inflammation and immune response.

Clinical significance

CD44 has been identified as a gene associated with cancer progression and metastatic disease. Aberrant expression of the CD44 gene is linked to a variety of diseases, including breast cancer, colorectal cancer, and gastric cancer.

See also

• Cell adhesion
• Glycoprotein
• Hyaluronic acid
• Osteopontin
• Collagens
• Matrix metalloproteinases
• Lymphocyte
• Hematopoiesis
• Tumor metastasis
• Inflammation
• Immune response
• Breast cancer
• Colorectal cancer
• Gastric cancer

References

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External links

• CD44 at WikiMD

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