AmpliChip CYP450 Test

AmpliChip CYP450 Test is a diagnostic tool used in the field of pharmacogenomics to determine an individual's genetic makeup in relation to the cytochrome P450 system. This system is responsible for the metabolism of many drugs and can influence an individual's response to certain medications. The AmpliChip CYP450 Test, developed by Roche, is designed to identify variations in two specific genes, CYP2D6 and CYP2C19, which are known to influence drug metabolism.

Overview

The AmpliChip CYP450 Test is a microarray-based test that uses DNA extracted from a patient's blood sample. The test identifies specific genetic variations in the CYP2D6 and CYP2C19 genes, which are part of the cytochrome P450 system. This system is responsible for metabolizing approximately 25% of all prescription drugs, including medications for depression, cardiovascular disease, and cancer.

Procedure

The AmpliChip CYP450 Test is performed using a blood sample taken from the patient. The DNA is extracted from the blood and then applied to the AmpliChip microarray. The microarray is then scanned to identify specific genetic variations in the CYP2D6 and CYP2C19 genes.

Clinical Significance

The results of the AmpliChip CYP450 Test can provide valuable information to healthcare providers about a patient's potential response to certain medications. This can help to guide treatment decisions and potentially avoid adverse drug reactions. For example, individuals with certain genetic variations may metabolize drugs more slowly or more quickly than average, which can affect the drug's efficacy and the risk of side effects.

Limitations

While the AmpliChip CYP450 Test can provide valuable information about an individual's potential response to certain medications, it is not a substitute for clinical judgment. Healthcare providers must consider other factors, such as the patient's overall health, other medications they are taking, and their lifestyle, when making treatment decisions.

See Also

• Pharmacogenomics
• Cytochrome P450
• Roche

References

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