Amlodipine/benazepril: Difference between revisions
CSV import |
CSV import |
||
| Line 7: | Line 7: | ||
== Medical Uses == | == Medical Uses == | ||
Amlodipine/benazepril is primarily prescribed for the management of hypertension. By lowering blood pressure, it helps to prevent complications such as [[stroke]], [[myocardial infarction]], and [[kidney failure]]. The combination of a calcium channel blocker and an ACE inhibitor provides a synergistic effect, | Amlodipine/benazepril is primarily prescribed for the management of hypertension. By lowering blood pressure, it helps to prevent complications such as [[stroke]], [[myocardial infarction]], and [[kidney failure]]. The combination of a calcium channel blocker and an ACE inhibitor provides a synergistic effect, making it more effective than either drug alone in certain patients. | ||
== Mechanism of Action == | == Mechanism of Action == | ||
| Line 13: | Line 13: | ||
=== Amlodipine === | === Amlodipine === | ||
Amlodipine is a [[dihydropyridine]] calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle. This action | Amlodipine is a [[dihydropyridine]] calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle. This action leads to vasodilation, or the widening of blood vessels, which reduces peripheral vascular resistance and lowers blood pressure. | ||
=== Benazepril === | === Benazepril === | ||
| Line 19: | Line 19: | ||
[[File:Benazepril.svg|Benazepril structure|thumb|left]] | [[File:Benazepril.svg|Benazepril structure|thumb|left]] | ||
Benazepril is an ACE inhibitor. It functions by blocking the conversion of [[angiotensin I]] to [[angiotensin II]], a potent vasoconstrictor. By reducing the levels of angiotensin II, benazepril decreases vasoconstriction and | Benazepril is an ACE inhibitor. It functions by blocking the conversion of [[angiotensin I]] to [[angiotensin II]], a potent vasoconstrictor. By reducing the levels of angiotensin II, benazepril decreases vasoconstriction and aldosterone secretion, leading to vasodilation and reduced blood pressure. | ||
== Side Effects == | == Side Effects == | ||
Common side effects of amlodipine/benazepril include [[dizziness]], [[headache]], [[cough]], and [[edema]] (swelling). | Common side effects of amlodipine/benazepril include [[dizziness]], [[headache]], [[cough]], and [[edema]] (swelling). More serious side effects can occur, such as [[angioedema]], [[hyperkalemia]], and [[renal impairment]]. Patients should be monitored for these adverse effects, especially when starting the medication or adjusting the dose. | ||
== Contraindications == | == Contraindications == | ||
| Line 37: | Line 37: | ||
* [[Benazepril]] | * [[Benazepril]] | ||
[[Category:Antihypertensive | [[Category:Antihypertensive combinations]] | ||
[[Category: | [[Category:Calcium channel blockers]] | ||
[[Category:ACE inhibitors]] | |||
Latest revision as of 17:15, 5 March 2025
Amlodipine/Benazepril[edit]
Amlodipine/benazepril is a combination medication used in the treatment of hypertension (high blood pressure). It combines two active ingredients: amlodipine, a calcium channel blocker, and benazepril, an angiotensin-converting enzyme inhibitor (ACE inhibitor). This combination is effective in lowering blood pressure by relaxing blood vessels and reducing the workload on the heart.
Medical Uses[edit]
Amlodipine/benazepril is primarily prescribed for the management of hypertension. By lowering blood pressure, it helps to prevent complications such as stroke, myocardial infarction, and kidney failure. The combination of a calcium channel blocker and an ACE inhibitor provides a synergistic effect, making it more effective than either drug alone in certain patients.
Mechanism of Action[edit]
Amlodipine[edit]
Amlodipine is a dihydropyridine calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle. This action leads to vasodilation, or the widening of blood vessels, which reduces peripheral vascular resistance and lowers blood pressure.
Benazepril[edit]
Benazepril is an ACE inhibitor. It functions by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. By reducing the levels of angiotensin II, benazepril decreases vasoconstriction and aldosterone secretion, leading to vasodilation and reduced blood pressure.
Side Effects[edit]
Common side effects of amlodipine/benazepril include dizziness, headache, cough, and edema (swelling). More serious side effects can occur, such as angioedema, hyperkalemia, and renal impairment. Patients should be monitored for these adverse effects, especially when starting the medication or adjusting the dose.
Contraindications[edit]
Amlodipine/benazepril is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy. It should not be used during pregnancy due to the risk of fetal harm. Patients with severe renal impairment or hepatic impairment should use this medication with caution.
