Mephentermine

Mephentermine is a cardiac stimulant. It works by directly stimulating the heart muscle and increasing the output of blood from the heart. Mephentermine also promotes the release of norepinephrine (noradrenaline) in the body.

Uses

Mephentermine is used to treat low blood pressure (hypotension) that can occur during different types of anesthesia. It is also used to treat hypotension caused by other medical conditions or drugs.

Side Effects

Common side effects of mephentermine include palpitations, tachycardia, chest pain, tremor, anxiety, fear, restlessness, headache, nausea, and vomiting. Severe side effects can include hypertension, arrhythmia, and pulmonary edema.

Contraindications

Mephentermine is contraindicated in patients with hypersensitivity to the drug, pheochromocytoma, ventricular fibrillation, and hypertension.

Interactions

Mephentermine can interact with other drugs such as monoamine oxidase inhibitors, tricyclic antidepressants, and beta blockers.

Pharmacology

Mephentermine is a non-catecholamine sympathomimetic agent that increases cardiac output by direct stimulation of cardiac muscle and by causing peripheral vasoconstriction.

History

Mephentermine was first synthesized in the 1940s and has been used in medicine since the 1950s.

See Also

• Cardiac stimulant
• Hypotension
• Anesthesia
• Norepinephrine

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