Barnidipine

Barnidipine (also known as Vasexten or Hypovase) is a calcium channel blocker used for the treatment of hypertension (high blood pressure). It belongs to the dihydropyridine class of calcium channel blockers, which also includes drugs like amlodipine, nifedipine, and felodipine.

Etymology

The name "Barnidipine" is derived from the chemical name of the drug, which is (S)-3-(benzyl(phenyl)amino)ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Pharmacology

Barnidipine, like other calcium channel blockers, works by inhibiting the influx of calcium ions into vascular smooth muscle cells. This leads to a decrease in vascular resistance and a reduction in blood pressure. Barnidipine has a high vascular selectivity and a significant post-ischemic blood flow improving effect, which makes it suitable for patients with ischemic heart disease.

Side Effects

Common side effects of Barnidipine include headache, palpitations, flushing, and ankle swelling. Less common side effects include dizziness, fatigue, abdominal pain, and nausea.

Interactions

Barnidipine can interact with other medications, including beta blockers, ACE inhibitors, and diuretics. It can also interact with grapefruit juice, which can increase the concentration of the drug in the body and potentially lead to an overdose.

Dosage

The usual starting dose of Barnidipine is 10 mg once daily, which can be increased to 20 mg once daily if necessary. The drug should be taken in the morning, with or without food.

See Also

• Calcium channel blocker
• Hypertension
• Dihydropyridine

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Barnidipine

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  Barnidipine structure