Ergocryptine

Ergocryptine is an ergopeptine and one of the ergot alkaloids. It is a precursor for the synthesis of bromocriptine.

Chemistry

Ergocryptine is a complex molecule of the ergoline family. It contains a tripeptide structure attached to the basic ergoline ring in the same orientation as ergotamine, but it is unique among the ergopeptines in that it contains α-aminobutyric acid in its peptide moiety.

Biosynthesis

Ergocryptine is a secondary metabolite produced by the fungus Claviceps purpurea. The biosynthesis of ergocryptine begins with the condensation of L-tryptophan and dimethylallyl pyrophosphate to form the tetracyclic ergoline ring system.

Pharmacology

Ergocryptine acts as a potent dopamine receptor agonist. It has been used in the treatment of Parkinson's disease and other medical conditions.

See also

• Ergotamine
• Ergoline
• Bromocriptine

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References

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External links

• Ergocryptine at PubChem
• Ergocryptine at DrugBank

Further reading

• Smith, A., & Pennington, R. J. (1975). Ergocryptine and other constituents of ergot. Journal of the Chemical Society, Perkin Transactions 1, (0), 2375-2378.
• Schardl, C. L., Panaccione, D. G., & Tudzynski, P. (2006). Ergot alkaloids--biology and molecular biology. The Alkaloids: Chemistry and Biology, 63, 45-86.

Ergocryptine

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  Ergocryptine
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  Ergot alkaloid biosynthesis
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  Part 3 in biosynthesis of ergocryptine
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  Detail look at mechanism in biosynthesis of ergocryptine
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  Part 4 in biosynthesis of ergot alkaloid ergocryptine
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  Part 5 in the biosynthesis of ergocryptine