Streptokinase

Streptokinase is a thrombolytic medication and enzyme produced by streptococci bacteria. It is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. The use of streptokinase is contraindicated in cases of recent surgery, hemorrhagic stroke, or active bleeding.

Mechanism of Action

Streptokinase works by combining with plasminogen to form an active complex that can convert other plasminogen molecules into plasmin. Plasmin is an enzyme that breaks down fibrin, a protein that forms the framework of blood clots.

Side Effects

Common side effects of streptokinase include nausea, vomiting, low blood pressure, and bleeding. Serious side effects may include allergic reactions and major bleeding.

History

Streptokinase was discovered in 1933. It was the first thrombolytic medication to be approved for use in heart attacks.

See Also

• Thrombolysis
• Fibrinolysis
• Myocardial infarction

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References

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External Links

• Streptokinase on Drugs.com
• Streptokinase on PubMed

Streptokinase

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  Streptokinase surface model
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  Streptokinase PDB structure
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  Streptokinase salt bridge
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  Streptokinase-plasminogen complex