Nitrogen mustard: Difference between revisions
CSV import |
CSV import |
||
| Line 26: | Line 26: | ||
{{stub}} | {{stub}} | ||
<gallery> | |||
File:Ethyl-S.svg|Ethyl-S chemical structure | |||
File:Chlormethine.svg|Chlormethine chemical structure | |||
File:Trichlormethine.svg|Trichlormethine chemical structure | |||
</gallery> | |||
Latest revision as of 02:02, 18 February 2025
Nitrogen Mustard is a type of chemotherapeutic agent derived from Mustard gas. It was among the first chemotherapy drugs to be developed and is part of a group of medicines called alkylating agents.
History[edit]
Nitrogen Mustard was first synthesized in the 1930s, but its potential as a cancer treatment was not realized until the 1940s. During World War II, it was observed that soldiers exposed to mustard gas had lower white blood cell counts. This led to the idea that mustard gas derivatives could be used to treat cancer, a disease characterized by rapidly dividing cells.
Mechanism of Action[edit]
Nitrogen Mustard works by binding to the DNA in cells and causing cross-linking of the DNA strands. This prevents the DNA from being correctly copied when the cell divides, which in turn leads to cell death. Because cancer cells divide more rapidly than normal cells, they are more likely to be affected by this mechanism.
Uses[edit]
Nitrogen Mustard is used to treat a variety of cancers, including Hodgkin's lymphoma, Non-Hodgkin lymphoma, Chronic lymphocytic leukemia, and Lung cancer. It is also used in some types of immunotherapies.
Side Effects[edit]
Like all chemotherapy drugs, Nitrogen Mustard has potential side effects. These can include nausea, vomiting, hair loss, and a decrease in blood cell counts. More serious side effects can include lung damage and secondary cancers.
