Lurtotecan

Lurtotecan is a topoisomerase inhibitor, specifically a topoisomerase I inhibitor, that is used in the treatment of various types of cancer. It is a semi-synthetic derivative of camptothecin, a natural product extracted from the Chinese Happy Tree (Camptotheca acuminata).

Mechanism of Action

Lurtotecan inhibits the enzyme topoisomerase I, which is essential for DNA replication. By inhibiting this enzyme, Lurtotecan prevents the unwinding of DNA, thereby inhibiting DNA replication and cell division. This leads to cell death and the reduction of the tumor size.

Clinical Use

Lurtotecan has been used in the treatment of various types of cancer, including ovarian cancer, small cell lung cancer, and colorectal cancer. It is usually administered as an intravenous infusion.

Side Effects

Like other chemotherapy drugs, Lurtotecan can cause a number of side effects. These can include nausea, vomiting, diarrhea, and myelosuppression, which can lead to a decrease in the number of white blood cells and increase the risk of infection.

Research

Research is ongoing into the use of Lurtotecan in combination with other chemotherapy drugs, and in different types of cancer. Early results suggest that it may be particularly effective in the treatment of glioblastoma, a type of brain tumor.

See Also

• Topoisomerase inhibitor
• Camptothecin
• Chemotherapy

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