Oxilofrine: Difference between revisions

Latest revision as of 16:30, 16 February 2025

Oxilofrine[edit]

Oxilofrine is a sympathomimetic amine that is used as a stimulant and vasodilator. It is chemically related to ephedrine and is known for its effects on the cardiovascular system.

Pharmacology[edit]

Oxilofrine acts primarily as a beta-adrenergic receptor agonist. It stimulates the release of norepinephrine and epinephrine, which leads to increased heart rate and blood pressure. This makes it effective in treating certain cardiac conditions and hypotension.

Mechanism of Action[edit]

The primary mechanism of action of oxilofrine involves the stimulation of beta-1 and beta-2 adrenergic receptors. This results in increased cardiac output and bronchodilation, making it useful in conditions where increased cardiac performance is desired.

Medical Uses[edit]

Oxilofrine is used in the treatment of orthostatic hypotension and other conditions where increased cardiac output is beneficial. It is sometimes used off-label for its stimulant properties.

Side Effects[edit]

Common side effects of oxilofrine include tachycardia, palpitations, and hypertension. In some cases, it may cause anxiety, insomnia, and tremors.

Legal Status[edit]

Oxilofrine is banned by many sports organizations due to its performance-enhancing effects. It is considered a prohibited substance by the World Anti-Doping Agency (WADA).

Related Pages[edit]

This article is a stub related to pharmacology. You can help WikiMD by expanding it!

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-'''Oxilofrine''' (also known as '''methylsynephrine''', '''hydroxyephrine''', '''oxyephrine''', and '''4-HMP''') is a [[stimulant]] compound. It is often used as an ingredient in [[dietary supplement]]s but has been associated with adverse cardiovascular events in certain populations.
+== Oxilofrine ==
-== History ==
+[[File:Oxilofrin_Structural_Formulae_V.1.svg|thumb|right|Structural formula of Oxilofrine]]
-Oxilofrine was originally developed in the 1970s by the pharmaceutical company [[Boehringer Ingelheim]]. It was marketed as a pharmaceutical drug in Europe for the treatment of [[hypotension]] (low blood pressure). However, it was never approved for use in the United States by the [[Food and Drug Administration]] (FDA).
+'''Oxilofrine''' is a [[sympathomimetic amine]] that is used as a [[stimulant]] and [[vasodilator]]. It is chemically related to [[ephedrine]] and is known for its effects on the [[cardiovascular system]].
-== Use in Dietary Supplements ==
+== Pharmacology ==
-Despite not being approved for use in the United States, oxilofrine has been found in various dietary supplements. It is often marketed as a weight loss aid, energy booster, and performance enhancer. However, the FDA has issued warnings about the use of dietary supplements containing oxilofrine, stating that they are adulterated and illegal.
+Oxilofrine acts primarily as a [[beta-adrenergic receptor]] agonist. It stimulates the release of [[norepinephrine]] and [[epinephrine]], which leads to increased heart rate and [[blood pressure]]. This makes it effective in treating certain [[cardiac conditions]] and [[hypotension]].
-== Health Risks ==
+=== Mechanism of Action ===
-The use of oxilofrine has been associated with several health risks. These include increased heart rate and blood pressure, chest pain, cardiac arrest, and in some cases, death. The risk is particularly high in individuals with pre-existing cardiovascular conditions.
+The primary mechanism of action of oxilofrine involves the stimulation of beta-1 and beta-2 adrenergic receptors. This results in increased cardiac output and bronchodilation, making it useful in conditions where increased cardiac performance is desired.
+== Medical Uses ==
+Oxilofrine is used in the treatment of [[orthostatic hypotension]] and other conditions where increased cardiac output is beneficial. It is sometimes used off-label for its stimulant properties.
+== Side Effects ==
+Common side effects of oxilofrine include [[tachycardia]], [[palpitations]], and [[hypertension]]. In some cases, it may cause [[anxiety]], [[insomnia]], and [[tremors]].
 == Legal Status ==
-In many countries, including the United States, oxilofrine is considered a banned substance in athletic competitions. The [[World Anti-Doping Agency]] (WADA) includes oxilofrine on its list of prohibited substances. Athletes who test positive for oxilofrine can face sanctions, including disqualification and suspension.
+Oxilofrine is banned by many [[sports organizations]] due to its performance-enhancing effects. It is considered a [[prohibited substance]] by the [[World Anti-Doping Agency]] (WADA).
+== Related Pages ==
-== See Also ==
+* [[Sympathomimetic drug]]
+* [[Beta-adrenergic agonist]]
+* [[Ephedrine]]
+* [[Norepinephrine]]
-* [[Dietary supplement]]
+{{Drug-stub}}
-* [[Stimulant]]
-* [[Food and Drug Administration]]
-* [[World Anti-Doping Agency]]
+[[Category:Sympathomimetic amines]]
 [[Category:Stimulants]]
-[[Category:Dietary supplements]]
+[[Category:Vasodilators]]
-[[Category:Pharmaceuticals]]
-{{Pharma-stub}}