CUMYL-FUBINACA: Difference between revisions

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'''CUMYL-FUBINACA''' is a [[synthetic cannabinoid]] that is also a [[full agonist]] for the [[cannabinoid receptors]], with an [[binding affinity]] of 0.58nM for [[CB1 receptor|CB1]] and 0.21nM for [[CB2 receptor|CB2]]. It was first identified in [[Japan]] in 2014.
{{DISPLAYTITLE:CUMYL-FUBINACA}}


==Chemistry==
== Overview ==
CUMYL-FUBINACA is an [[indazole]]-based synthetic cannabinoid. It is a potent [[agonist]] of the CB1 receptor with a binding affinity of 0.58nM. The chemical structure consists of a cumyl group, which is a common feature in this class of synthetic cannabinoids.
'''CUMYL-FUBINACA''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor]]s. It is part of a class of compounds that are often used in the production of [[designer drugs]]. These substances are frequently found in products marketed as "[[spice (drug)|spice]]" or "synthetic marijuana".


==Pharmacology==
== Chemical Structure ==
CUMYL-FUBINACA acts as a full agonist with a binding affinity of 0.58nM for CB1 and 0.21nM for CB2 cannabinoid receptors. The exact [[pharmacokinetics]] of CUMYL-FUBINACA within the body is unknown.
[[File:CUMYL-FUBINACA_structure.png|thumb|right|Chemical structure of CUMYL-FUBINACA]]
CUMYL-FUBINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is ''N''-[[(1-(4-fluorobenzyl)-1''H''-indazole-3-carbonyl]])-''L''-valine ''methyl ester''. The presence of the fluorobenzyl group is a distinguishing feature of this compound.


==Effects==
== Pharmacology ==
The effects of CUMYL-FUBINACA can be potent and severe. They can include [[euphoria]], [[relaxation]], [[perception changes]], and [[adverse effects]] such as [[nausea]], [[vomiting]], [[tachycardia]], [[hypertension]], and [[seizures]]. The severity of these effects is likely related to the high potency of the drug and its full agonist activity at the CB1 receptor.
CUMYL-FUBINACA acts as a full agonist at the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors, which are part of the [[endocannabinoid system]]. This system is involved in regulating a variety of physiological processes including mood, memory, and appetite. The activation of these receptors by CUMYL-FUBINACA can lead to psychoactive effects similar to those of [[tetrahydrocannabinol]] (THC), the active component of [[cannabis]].


==Legal Status==
== Effects and Toxicity ==
CUMYL-FUBINACA is a controlled substance in some countries, including the [[United States]], [[Japan]], and some [[European Union]] countries. It is often found in [[synthetic cannabis]] products, which are illegal in many jurisdictions.
The effects of CUMYL-FUBINACA can include euphoria, relaxation, altered perception, and in some cases, anxiety or paranoia. However, due to its potency, it can also lead to severe adverse effects such as [[tachycardia]], [[hypertension]], [[nausea]], [[vomiting]], and [[seizures]]. There have been reports of fatalities associated with its use, often due to its unpredictable potency and the lack of quality control in its production.


==See Also==
== Legal Status ==
CUMYL-FUBINACA is classified as a controlled substance in many countries due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and other [[new psychoactive substances]].
 
== Related Pages ==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
* [[Indazole]]
* [[Spice (drug)]]
* [[Endocannabinoid system]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]
[[Category:Cannabinoids]]
[[Category:Indazoles]]
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Latest revision as of 06:08, 16 February 2025


Overview[edit]

CUMYL-FUBINACA is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of a class of compounds that are often used in the production of designer drugs. These substances are frequently found in products marketed as "spice" or "synthetic marijuana".

Chemical Structure[edit]

Chemical structure of CUMYL-FUBINACA

CUMYL-FUBINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is N-(1-(4-fluorobenzyl)-1''H''-indazole-3-carbonyl)-L-valine methyl ester. The presence of the fluorobenzyl group is a distinguishing feature of this compound.

Pharmacology[edit]

CUMYL-FUBINACA acts as a full agonist at the CB1 and CB2 cannabinoid receptors, which are part of the endocannabinoid system. This system is involved in regulating a variety of physiological processes including mood, memory, and appetite. The activation of these receptors by CUMYL-FUBINACA can lead to psychoactive effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.

Effects and Toxicity[edit]

The effects of CUMYL-FUBINACA can include euphoria, relaxation, altered perception, and in some cases, anxiety or paranoia. However, due to its potency, it can also lead to severe adverse effects such as tachycardia, hypertension, nausea, vomiting, and seizures. There have been reports of fatalities associated with its use, often due to its unpredictable potency and the lack of quality control in its production.

Legal Status[edit]

CUMYL-FUBINACA is classified as a controlled substance in many countries due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and other new psychoactive substances.

Related Pages[edit]